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Drug repurposing for immune modulation in acute ischemic stroke.
Abstract Innate immune cells play a dualistic role in the evolution of ischemic brain damage, with classic phenotypes promoting injury, and alternatively activated M2 microglia/macrophages or N2 neutrophils providing tissue remodelling and repair. Recently, a number of drugs commonly used for other indications (i.e., azithromycin, minocycline, bexarotene, rosiglitazone, metformin) was reported to provide neuroprotection in preclinical stroke models by promoting immune polarization towards non-inflammatory, protective phenotypes. Repurposing drugs with a well-established safety profile should allow a reduction in t...
Source: Current Opinion in Pharmacology - December 1, 2015 Category: Drugs & Pharmacology Authors: Amantea D, Bagetta G Tags: Curr Opin Pharmacol Source Type: research