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Ameliorative effect of Xiaoyao - jieyu - san on post-stroke depression and its potential mechanisms
AbstractA stroke is a severe life-threatening disease with high fatality and disability rate. This investigation aimed to study the effect ofXiaoyao-jieyu-san (XYJY) on post-stroke depression (PSD) and its potential mechanisms. PSD rats were prepared using middle cerebral artery embolization (MCAO) and chronic unpredictable mild stress (CUMS), and divided into six groups (n = 10)—sham; MCAO; MCAO + CUMS (PSD); PSD + fluoxetine (1.84 mg/kg/day, 4 weeks); and PSD + XYJY (450 mg/kg/day and 900 mg/kg/day, 4 weeks). Body weight recording, despair swimming test, and sucrose preference test were performed a...
Source: Journal of Natural Medicines - September 7, 2018 Category: Drugs & Pharmacology Source Type: research