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Pre ‐ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting ER stress‐dependent autophagy via PERK and IRE1 signalings
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - February 7, 2017 Category: Research Authors: Dayun Feng, Bao Wang, Lei Wang, Neeta Abraham, Kai Tao, Lu Huang, Wei Shi, Yushu Dong, Yan Qu Tags: Original Article Source Type: research

Melatonin as an Antioxidant: Under Promises but Over Delivers
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 7, 2016 Category: Research Authors: Russel J. Reiter, Juan C. Mayo, Dun ‐Xian Tan, Rosa M. Sainz, Moises Alatorre‐Jimenez, Lilian Qin Tags: Review Source Type: research

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1‐dependent mechanism during ischemic‐stroke in mice
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - November 17, 2014 Category: Research Authors: Yang Yang, Shuai Jiang, Yushu Dong, Chongxi Fan, Lei Zhao, Xiangmin Yang, Juan Li, Shouyin Di, Liang Yue, Guobiao Liang, Russel J Reiter, Yan Qu Tags: Original Article Source Type: research

Alterations in the time course of expression of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model: effects of melatonin
This study was designed to evaluate the time course of expression of the Nox family, a major source of ROS, and whether melatonin, a potent scavenger of ROS, influences these parameters in a rat model of cerebral I/R caused by middle cerebral artery occlusion (MCAO). After 2 h occlusion, the filament was withdrawn to allow reperfusion. At 0 h, 3 h, 6 h, 12 h, 24 h and 48 h after reperfusion, brain tissue samples were obtained for assays. Among the Nox family, the mRNA and protein levels of Nox2 and Nox4 were increased both in the ischemic hemisphere and contralateral counterpart in the experimental I/R rats at 0 h after ...
Source: Journal of Pineal Research - May 1, 2014 Category: Research Authors: Haiying Li, Yang Wang, Dongxia Feng, Yin Liu, Min Xu, Anju Gao, Fengxuan Tian, Li Zhang, Yonghua Cui, Zhong Wang, Gang Chen Tags: Original Article Source Type: research

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha‐7 nicotinic receptor modulation and HO‐1 overexpression
In this study, we evaluated the neuroprotective/antioxidant mechanism of action of melatonin in organotypic hippocampal cultures (OHCs) as well as in photothrombotic stroke model in vivo. Melatonin (0.1, 1, and 10 μm) incubated postoxygen and glucose deprivation (OGD) showed a concentration‐dependent protection; maximum protection was achieved at 10 μm (90% protection). Next, OHCs were exposed to 10 μm melatonin at different post‐OGD times; the protective effect of melatonin was maintained at 0, 1, and 2 hr post‐OGD treatment, but it was lost at 6 hr post‐OGD. The protective effect of melatonin and the redu...
Source: Journal of Pineal Research - January 16, 2014 Category: Research Authors: Esther Parada, Izaskun Buendia, Rafael León, Pilar Negredo, Alejandro Romero, Antonio Cuadrado, Manuela G. López, Javier Egea Tags: Original Article Source Type: research

Melatonin improves neuroplasticity by upregulating the growth‐associated protein‐43 (GAP‐43) and NMDAR postsynaptic density‐95 (PSD‐95) proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral ischemia even during a long‐term recovery period
Abstract Recent evidence shows that the NMDAR postsynaptic density‐95 (PSD‐95), growth‐associated protein‐43 (GAP‐43), and matrix metalloproteinase‐9 (MMP‐9) protein enhance neuroplasticity at the subacute stage of stroke. Here, we evaluated whether melatonin would modulate the PSD‐95, GAP‐43, and MMP‐9 proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to experimental stroke. Adult male Sprague–Dawley rats were treated with melatonin (5 mg/kg) or vehicle at reperfusion onset after transient occlusion of the right middle cerebral artery (tMCAO) for 90 min. Animals...
Source: Journal of Pineal Research - January 13, 2014 Category: Research Authors: Wei‐Sheng Juan, Sheng‐Yang Huang, Che‐Chao Chang, Yu‐Chang Hung, Yu‐Wen Lin, Tsung‐Ying Chen, Ai‐Hua Lee, Ai‐Chiang Lee, Tian‐Shung Wu, E‐Jian Lee Tags: Original Article Source Type: research

Melatonin improves neuroplasticity by upregulating the growth‐associated protein 43 (GAP‐43) and NMDAR‐post‐synaptic density‐95 (PSD95) proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral ischemia even during a long‐term recovery period
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - December 18, 2013 Category: Research Authors: Wei‐Sheng Juan, Sheng‐Yang Huang, Che‐Chao Chang, Yu‐Chang Hung, Yu‐Wen Lin, Tsung‐Ying Chen, Ai‐Hua Lee, Ai‐Chiang Lee, Tian‐Shung Wu, E‐Jian Lee Tags: Original Article Source Type: research

Neuroprotective effect of melatonin against ischemia is partially mediated by alfa‐7 nicotinic receptor modulation and HO‐1 overexpression
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - December 18, 2013 Category: Research Authors: Esther Parada, Izaskun Buendia, Rafael León, Pilar Negredo, Alejandro Romero, Antonio Cuadrado, Manuela G. López, Javier Egea Tags: Original Article Source Type: research