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Drug: Melatonin
Procedure: Cataract Removal

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The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study)
Introduction Blue light information plays an important role in synchronising internal biological rhythm within the external environment. Circadian misalignment is associated with the increased risk of sleep disturbance, obesity, diabetes mellitus, depression, ischaemic heart disease, stroke and cancer. Meanwhile, blue light causes photochemical damage to the retina, and may be associated with age-related macular degeneration (AMD). At present, clear intraocular lenses (IOLs) and blue-blocking IOLs are both widely used for cataract surgery; there is currently a lack of randomised controlled trials to determine whether clear...
Source: BMJ Open - May 12, 2015 Category: Journals (General) Authors: Nishi, T., Saeki, K., Obayashi, K., Miyata, K., Tone, N., Tsujinaka, H., Yamashita, M., Masuda, N., Mizusawa, Y., Okamoto, M., Hasegawa, T., Maruoka, S., Ueda, T., Kojima, M., Matsuura, T., Kurumatani, N., Ogata, N. Tags: Open access, Epidemiology, Ophthalmology Protocol Source Type: research