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Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats.
Abstract Rosiglitazone, a potent peroxisome proliferator-activated receptor (PPAR)-γ agonist, has been shown to confer neuroprotective effects in stroke and spinal cord injury, but its role in the traumatic brain injury (TBI) is still controversial. Using a controlled cortical impact model in rats, the current study was designed to determine the effects of rosiglitazone treatment (6 mg/kg at 5 min, 6 h and 24 h post injury) upon inflammation and histological outcome at 21 d after TBI. In addition, the effects of rosiglitazone upon inflammatory cytokine transcription, vestibulomotor behavior and spatial memor...
Source: Biochemical and Biophysical Research communications - March 3, 2016 Category: Biochemistry Authors: Liu H, Rose ME, Culver S, Ma X, Dixon CE, Graham SH Tags: Biochem Biophys Res Commun Source Type: research