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Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment
Abstract: Evidences exist that dopamine is involved in T-cell homeostasis. Here, we investigated if daily treatment with levodopa (20mg/kg)/benserazide (15mg/kg) regulates the number of T-cells in the blood of Sprague Dawley rats subjected to transient occlusion of the middle cerebral artery (tMCAO). T-cells and associated inflammatory cytokines were analyzed in the blood one week after tMCAO. Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa tr...
Source: Journal of Neuroimmunology - March 10, 2014 Category: Allergy & Immunology Authors: Enida Kuric, Karsten Ruscher Tags: Short Communications Source Type: research