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Specialty: Biomedical Science
Drug: Nifedipine
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Therapeutic Differences in 24 ‐h Ambulatory Blood Pressures in Patients Switched Between Bioequivalent Nifedipine Osmotic Systems With Differing Delivery Technologies
This study examined the validity of the assumption that these interchangeable, but different, delivery technologies are therapeutically equivalent in maintaining systolic blood pressure (SBP) control throughout the entire dosing interval. We used 24‐h Ambulatory Blood Pressure Monitoring to objectively examine whether formulation switches changed population SBP >2 mmHg (reflecting 6% increased stroke mortality) and in what proportion of patients SBP changed ≥6 mmHg (risking unnecessary therapeutic alterations). When 20 patients, previously receiving 60‐mg‐once‐daily Nifedipine‐GITS, were switched to Mylan‐...
Source: Clinical and Translational Science - February 23, 2017 Category: Biomedical Science Authors: PT Pollak, RJ Herman, RD Feldman Tags: ARTICLE Source Type: research
