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Brain proteomics identifies potential simvastatin targets in acute phase of stroke in a rat embolic model
Abstract Finding an efficient neuroprotectant is of urgent need in the field of stroke research. The goal of this study was to test the effect of acute simvastatin administration after stroke in a rat embolic model and to explore its mechanism of action through brain proteomics. To that end, male Wistar rats were subjected to a Middle Cerebral Arteria Occlusion and simvastatin (20 mg/kg s.c) (n = 11) or vehicle (n = 9) were administered 15 min after. To evaluate the neuroprotective mechanisms of simvastatin, brain homogenates after 48 h were analyzed by two‐dimensional fluorescence Difference in Gel Electrophoresi...
Source: Journal of Neurochemistry - April 30, 2014 Category: Neurology Authors: Mireia Campos‐Martorell, Nelida Salvador, Marta Monge, Francesc Canals, Lidia García‐Bonilla, Mar Hernández‐Guillamon, María Irene Ayuso, Pilar Chacón, Anna Rosell, Alberto Alcazar, Joan Montaner Tags: Original Article Source Type: research

Brain proteomics identifies possible simvastatin targets in acute phase of stroke in a rat embolic model
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - March 24, 2014 Category: Neurology Authors: Mireia Campos‐Martorell, Nelida Salvador, Marta Monge, Francesc Canals, Lidia García‐Bonilla, Mar Hernández‐Guillamon, María Irene Ayuso, Pilar Chacón, Anna Rosell, Alberto Alcazar, Joan Montaner Tags: Original Article Source Type: research