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072 The oblique path of a transverse lesion
A 38-year-old man presented in September 2016 with left hand numbness which progressed over 2 days to disabling weakness of his left arm and leg. He initially presented to a stroke unit, stroke being ruled out by brain MRI. An MRI spine showed an intramedullary lesion extending from C2-C7. He was referred to neurosurgery who queried an astrocytoma and performed a biopsy. Biopsy demonstrated a demyelinat- ing lesion leading to referral to neurology. Following a battery of investigations, visual evoked potentials showed left sided delay and positive serum aquaporin-4 antibodies (AQP4-Abs). A diagnosis of Neuromyelitis Optica...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Kesserwani, J., Cooper, R., Wickremaratchi, M., Palace, J., Fisniku, L. Tags: Poster Presentations Source Type: research

Anti glutamic acid decarboxylase antibody mediated encephalopathy while on etanercept in a patient with multiple autoimmune diseases
A 39 year old lady presented with an altered mental state and unsteadiness of gait. She had a history of juvenile idiopathic arthritis, autoimmune thyroiditis and alopecia, protein S deficiency with vena cava thrombosis, previous excision of ovarian mass and vasculitic rash. There was a previous history of ovarian mass and her immunomodulatory therapy for arthritis over the previous year was Etanercept. She used recreational cannabis but denied any other illicit drug usage. Her affect was variable and at times inappropriate with frequent laughter. She would spit regularly. There was anxiety and a prevailing sensation of do...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: MacDougall, N., Waddell, B., O'Riordan, J. I. Tags: Immunology (including allergy), Brain stem / cerebellum, Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Stroke, Drugs misuse (including addiction), Connective tissue disease, Musculoskeletal syndromes Association of British Source Type: research