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Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes
Altered neuronal connectivity in peri-infarct tissue is an important contributor to both the spontaneous recovery of neurological function that commonly develops after stroke and improvements in recovery that ...
Source: Journal of Neuroinflammation - January 9, 2019 Category: Neurology Authors: Wai Ping Yew, Natalia D. Djukic, Jaya S. P. Jayaseelan, Frederick R. Walker, Karl A. A. Roos, Timothy K. Chataway, Hakan Muyderman and Neil R. Sims Tags: Research Source Type: research

Attenuation of acute stroke injury in rat brain by minocycline promotes blood¿brain barrier remodeling and alternative microglia/macrophage activation during recovery
Conclusions: Early minocycline treatment against reperfusion injury significantly promotes neurovascular remodeling during stroke recovery by reducing brain tissue loss, enhancing TJP expression in ischemic brains and facilitating neuroprotective phenotype alternative activation of microglia/macrophages.
Source: Journal of Neuroinflammation - February 10, 2015 Category: Neurology Authors: Yirong YangVictor SalayandiaJeffrey ThompsonLisa YangEduardo EstradaYi Yang Source Type: research