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Probing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs
Randomized Controlled Trials (RCTs) are considered the gold standard for measuring the efficacy of medical interventions. However, RCTs are expensive, and use a limited population. Techniques to estimate the effects of stroke interventions from observational data that minimize confounding would be useful. We used regression discontinuity design (RDD), a technique well-established in economics, on the Get With The Guidelines-Stroke (GWTG-Stroke) data set. RDD, based on regression, measures the occurrence of a discontinuity in an outcome (e.g., odds of home discharge) as a function of an intervention (e.g., alteplase) that b...
Source: Frontiers in Neurology - September 1, 2020 Category: Neurology Source Type: research

Economic evaluation of endovascular treatment for acute ischaemic stroke in Thailand
Conclusions EVT represents good value for money in the Thai context, both when provided to patients eligible for intravenous alteplase, and when provided alone to those who are ineligible for intravenous alteplase.
Source: BMJ Open - September 27, 2022 Category: General Medicine Authors: Rattanavipapong, W., Worakijthamrongchai, T., Soboon, B., Luankongsomchit, V., Kongmuangpuk, M., Isaranuwatchai, W., Teerawattananon, Y., Nilanont, Y. Tags: Open access, Health economics Source Type: research

Cost-effective analysis of mechanical thrombectomy alone in the treatment of acute ischaemic stroke: a Markov modelling study
Conclusions MT alone was cost-effective compared with MT with alteplase in China. However, cautions are needed to extend this conclusion to regions outside of China.
Source: BMJ Open - April 6, 2022 Category: General Medicine Authors: Han, M., Qin, Y., Tong, X., Ji, L., Zhao, S., Liu, L., Chen, J., Liu, A. Tags: Open access, Health economics Source Type: research