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Source: Neurology
Drug: Activase

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Total 35 results found since Jan 2013.

Outcome after stroke thrombolysis in patients >80 years treated within 3 hours vs >3-4.5 hours
Conclusions: In this observational study, unselected patients >80 years of age treated with IVT after 3 hours vs earlier had a slightly higher rate of SICH and similar unadjusted functional outcome but poorer adjusted outcome. The absolute difference between the treatment groups is small, and elderly patients should not be denied IVT in the later time window solely because of age without other contraindications.
Source: Neurology - October 9, 2017 Category: Neurology Authors: Ahmed, N., Lees, K. R., Ringleb, P. A., Bladin, C., Collas, D., Toni, D., Ford, G. A., And the SITS Investigators Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials
Conclusions: Tenecteplase may offer greater recanalization efficacy compared to alteplase, possibly exaggerated in patients with complete vessel occlusions on baseline CTA.
Source: Neurology - July 3, 2017 Category: Neurology Authors: Bivard, A., Huang, X., Levi, C. R., Spratt, N., Campbell, B. C. V., Cheripelli, B. K., Kalladka, D., Moreton, F. C., Ford, I., Bladin, C. F., Davis, S. M., Donnan, G. A., Muir, K. W., Parsons, M. W. Tags: CT, MRI, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Trends in Alteplase Utilization in Louisianas Level III Hospitals (P4.272)
Conclusions:The treatment rate is increasing in Level III hospitals in Louisiana and is higher than the latest national Primary Stroke Center rate. Half of registered patients presented within 4.5hrs of LSN. Documentation of the reason for not getting alteplase improved. The disability associated with perceived minimal deficits is a target for enhanced education in determining eligibility for alteplase.Disclosure: Dr. Navalkele has nothing to disclose. Dr. Hargrove has nothing to disclose. Dr. Chernyshev has nothing to disclose. Dr. Acosta has nothing to disclose. Dr. DeAlvare has nothing to disclose. Dr. Hidalgo has nothi...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Navalkele, D., Hargrove, P., Chernyshev, O., Acosta, J., DeAlvare, L., Hidalgo, G., El Khoury, R., Martin-Schild, S. Tags: Thrombolysis and Acute Evaluation in Ischemic Stroke Source Type: research

Intravenous thrombolytic treatment of acute ischemic stroke in patients older and younger than 80 years: experience from one hospital (p4.275)
Conclusions:We found that IV thrombolysis still has benefit in people older than 80 years old but treatment decision should be taken with caution in well selected cases.Study Supported by: Not applicableDisclosure: Dr. Bayona has nothing to disclose. Dr. Diaz-Cruz has received research support from EMD Serono and Verily. Dr. Valencia-Mendoza has nothing to disclose. Dr. Díaz has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bayona, H., Diaz-Cruz, C., Valencia-Mendoza, C., Diaz, A. Tags: Thrombolysis and Acute Evaluation in Ischemic Stroke Source Type: research

Stroke system of care in Louisiana (P6.261)
Conclusions:After LERN’s recognition of stroke facility designations, implementation of education for stroke providers and quality improvement process, the proportion of patients treated with IV tPA has doubled in the state of Louisiana over a 5-year period. LERN’s Statewide stroke system of care has been instrumental in facilitating this progress.Disclosure: Dr. Navalkele has nothing to disclose. Dr. Hargrove has nothing to disclose. Dr. Chernyshev has nothing to disclose. Dr. Acosta has nothing to disclose. Dr. DeAlvare has nothing to disclose. Dr. Hidalgo has nothing to disclose. Dr. El Khoury has nothing to...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Navalkele, D., Hargrove, P., Chernyshev, O., Acosta, J., DeAlvare, L., Hidalgo, G., El Khoury, R., Martin-Schild, S. Tags: Cerebrovascular Disease Systems of Care and Health Policy Source Type: research

A rare cause of stroke in young: PHACE syndrome (P1.253)
Conclusions:Neurocutaneous syndromes are typically diagnosed in childhood and can be a rare cause of stroke in young. Our patient suffered an ischemic stroke secondary to sequelae of undiagnosed PHACE syndrome. Early identification of neurocutaneous syndromes allows for proper surveillance, evaluation, and preventative education for development of complications.Disclosure: Dr. Fitzgerald has nothing to disclose. Dr. Chandra has nothing to disclose. Dr. Dannenbaum has nothing to disclose. Dr. Sharrief has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Fitzgerald, K., Chandra, S., Dannenbaum, M., Sharrief, A. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Analysis of Run Sheets of EMS Serving a Metropolitan Comprehensive Stroke Center (P1.268)
Conclusions:Patients with acute stroke transported by EMS have better quality metrics and higher chance of receiving acute treatment. EMS documented assessment allows for the diagnosis or stroke in general but cannot identify LVO because the assessment of cortical signs is very limited.Disclosure: Dr. Hussein has nothing to disclose. Dr. Kashyap has nothing to disclose. Dr. Erickson has nothing to disclose. Dr. Forsberg has nothing to disclose. Dr. Burnett has nothing to disclose. Dr. Stanfield has nothing to disclose. Dr. Wewerka has nothing to disclose. Dr. Terwilliger has nothing to disclose. Dr. Hanson has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Hussein, H., Kashyap, B., Erickson, L., Forsberg, A., Burnett, A., Stanfield, S., Wewerka, S., Terwilliger, A., Hanson, L. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research

Lytic therapy and mechanical thrombecomty over tele-stroke, a comprehensive stroke center experience (P1.275)
Conclusions:Our study shows that our Tele stroke program had evolved over time to involve more sites throughout the state of South Carolina. Post IV tPA sICH was within the expected range.Disclosure: Dr. Al Kasab has nothing to disclose. Dr. Debenham has nothing to disclose. Dr. Jones has nothing to disclose. Dr. Holmstedt has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kasab, S. A., Debenham, E., Jones, D. J., Holmstedt, C. A. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research

4-year-old boy with acute ischemic stroke treated with intravenous tissue plasminogen activase. (P1.285)
Conclusions:The TIPS trial is underway, which utilizes a classic safety dose finding method to select a safe dose of IV tPA. The child in our case was successfully treated with a dose of 0.75 mg/kg of IV tPA. It has been suggested the appropriate dose may actually be higher than the standard used in adults due to the developmental trajectory of the fibrinolytic system during childhood, as children have lower endogenous tPA and higher plasminogen activator inhibitor-1 levels.Disclosure: Dr. Derani has nothing to disclose. Dr. Kassab has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Derani, T., Kassab, M. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Characteristics of Code Stroke Cases in a Level 1 Trauma U.S. Military Treatment Facility: Comparison with a Civilian Stroke Center (P3.265)
Conclusions:The proportion of code strokes ultimately diagnosed with AISor TIA in our facility is lower than that reported in a civilian stroke center, and the proportion of functional diagnoses is higher. Further studies are needed to describe the reasons for these differences, which may be unique to military populations.Disclosure: Dr. Koehn has nothing to disclose. Dr. Williams has nothing to disclose. Dr. Chao has nothing to disclose. Dr. Frattalone has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Koehn, T., Williams, J., Chao, W., Frattalone, A. Tags: Cerebrovascular Disease Epidemiology Source Type: research

Myocardial Wall Rupture Following tPA Administration: A Case Report and Review of the Literature (P3.270)
Conclusions:Although the frequency of pericarditis, mural hemorrhage and subsequent myocardial rupture after MI is declining following PCI, clinicians should be mindful of this potential complication in tPA treated patients with recent MI. Further, cardiac wall rupture should be considered in patients who develop acute hypotension and bradycardia following tPA administration. The current literature is limited and insufficient to provide generalizable guidance on managing AIS patients with recent MI.Disclosure: Dr. Neu has nothing to disclose. Dr. Albright has nothing to disclose. Dr. Lyerly has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Neu, M., Albright, K., Lyerly, M. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Intrapartum thrombolysis in acute stroke patient (P3.295)
Conclusions:The AHA/ASA guidelines recommend alteplase for moderate to severe strokes in pregnancy provided the benefit justifies the potential risk to the fetus and mother. Although, we report successful administration of intravenous alteplase during active labor without any complication to mother and baby, more data is needed to confirm the efficacy and safety in this patient population. A retrospective cohort study of 15 cases of alteplase in pregnancy did not demonstrate any increase in adverse events when compared to the non-pregnant females but none of them were in labor.Disclosure: Dr. Kohli has nothing to disclose....
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kohli, D., Shekhar, S., Sreenivasan, V., Sugg, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Outcomes of Endovascular Thrombectomy with and without thrombolysis for acute large artery ischaemic stroke at a Tertiary Stroke Centre (P5.259)
Conclusions:Our study supports the use of direct EVT for patients in whom alteplase is contraindicated. We observed no additional benefit of adding intravenous thrombolysis to EVT but the estimates are imprecise due to small numbers. Nevertheless, the results are consistent with observational data from other centres, and support a randomised controlled trial of EVT vs. EVT with bridging alteplase.Disclosure: Dr. Wee has nothing to disclose. Dr. Hankey has received personal compensation for activities with Bayer Pharmaceuticals and theheart.org (Medscape) as a speaker.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wee, C. K., Hankey, G. Tags: Acute Cerebrovascular Interventional Therapies Source Type: research

Primary Aspiration Thrombectomy in Acute Ischemic Stroke: A Single-Center Experience (P5.262)
Conclusions:Our single-center experience shows that primary aspiration thrombectomy can yield both favorable angiographic and clinical outcomes with minimal adverse effect.Disclosure: Dr. Asaithambi has nothing to disclose. Dr. Castle has nothing to disclose. Dr. Stein has nothing to disclose. Dr. Asaithambi has nothing to disclose. Dr. Hanson has nothing to disclose. Dr. Asaithambi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Asaithambi, G., Castle, A., Stein, L., Wallace-Jackson, A., Hanson, S., Lassig, J. Tags: Acute Cerebrovascular Interventional Therapies Source Type: research

Local Experience with a new retrievable stent (ERIC) in academic Center (P5.269)
Conclusions:In this study, the use of new ERIC retrieval device was technically feasible, safe, and effective in acute ischemic stroke with large-vessel occlusionDisclosure: Dr. Alshaer has nothing to disclose. Dr. Alturkustani has nothing to disclose. Dr. Khoja has nothing to disclose. Dr. Almekhlafi has nothing to disclose. Dr. Ayoub has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: AlShaer, D., Alturkustani, A., Khoja, A., Almekhlafi, M., Ayoub, O. Tags: Acute Cerebrovascular Interventional Therapies Source Type: research