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Different effects of arginine vasopressin on high ‐mobility group box 1 expression in astrocytes isolated from stroke‐prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
Summary Stroke‐prone spontaneously hypertensive rats (SHRSP/Izm) develop severe hypertension and astrocytic oedema following ischaemic stimulation. During ischaemic stress high‐mobility group box 1 (Hmgb1) expression in astrocytes is induced, and subsequently potentiates deterioration of the brain due to ischaemic injury, which manifests as both cerebral inflammation and astrocytic oedema. Arginine vasopressin (AVP) induces brain injury and increases astrocytic swelling. After stroke, Hmgb1 and peroxiredoxin (Prx) are released at different times and activate macrophages in the brain via Toll‐like receptors (Tlr2s). T...
Source: International Journal of Experimental Pathology - April 28, 2016 Category: Pathology Authors: Kazuo Yamagata, Natumi Sone, Sari Suguyama, Toru Nabika Tags: Original Article Source Type: research

Different effects of arginine vasopressin on high‐mobility group box 1 expression in astrocytes isolated from stroke‐prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
Summary Stroke‐prone spontaneously hypertensive rats (SHRSP/Izm) develop severe hypertension and astrocytic oedema following ischaemic stimulation. During ischaemic stress high‐mobility group box 1 (Hmgb1) expression in astrocytes is induced, and subsequently potentiates deterioration of the brain due to ischaemic injury, which manifests as both cerebral inflammation and astrocytic oedema. Arginine vasopressin (AVP) induces brain injury and increases astrocytic swelling. After stroke, Hmgb1 and peroxiredoxin (Prx) are released at different times and activate macrophages in the brain via Toll‐like receptors (Tlr2s). T...
Source: International Journal of Experimental Pathology - April 28, 2016 Category: Pathology Authors: Kazuo Yamagata, Natumi Sone, Sari Suguyama, Toru Nabika Tags: Original Article Source Type: research