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E-005 Preliminary results of the SUMMIT NZ ischemic stroke trial: MonoPoint(R) embolectomy featuring a novel 088 aspiration catheter and specialized delivery catheter
ConclusionsPreliminary findings suggest that first-line aspiration embolectomy using a novel MonoPoint® system including an 0.088" inner diameter aspiration catheter achieves a high rate of arterial revascularization with an acceptable safety profile. A full report on enrollment and results are to be presented.Disclosures S. Brew: 1; C; Route 92 Medical. 2; C; Route 92 Medical, Microvention. B. McGuinness: 1; C; Route 92 Medical. 2; C; Route 92 Medical. J. Caldwell: 1; C; Route 92 Medical. 2; C; Route 92 Medical. S. Lee: 1; C; Route 92 Medical. P. Barber: None. A. Holden: 2; C; Medtronic, Gore, Boston Scientific. T. Wu...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Brew, S., McGuinness, B., Caldwell, J., Lee, S., Barber, P., Holden, A., Wu, T., Krauss, M., Laing, A., Collecutt, W., Liebeskind, D., Hetts, S. Tags: Electronic poster abstracts Source Type: research

Tocilizumab Reduces Vasospasms, Neuronal Cell Death, and Microclot Formation in a Rabbit Model of Subarachnoid Hemorrhage
AbstractEarly brain injury (EBI), delayed cerebral vasospasm (DCVS), and delayed cerebral ischemia (DCI) are common complications of subarachnoid hemorrhage (SAH). Inflammatory processes in the cerebrospinal fluid (CSF) are one of the causes for such complications. Our aim to study the effects of an IL-6 receptor antagonist (Tocilizumab) examines the occurrence of DCVS, neuronal cell death, and microclot formation in an acute SAH rabbit model. Twenty-nine New Zealand white rabbits were randomized into one of three groups as the SAH, SAH + Tocilizumab, and sham groups. In SAH groups, hemorrhage was induced by extracranial-i...
Source: Translational Stroke Research - January 6, 2021 Category: Neurology Source Type: research

Atrial fibrillation in acute coronary syndrome: patient characteristics and appropriate utilisation of anti-thrombotic therapy in New Zealand (ANZACS-QI 39).
CONCLUSION: In New Zealand, one in seven patients presenting with ACS have AF, a third being new-onset AF. Antithrombotic management is inconsistent, with underutilisation of anticoagulants, particularly the DAT regimen, and is inadequately informed by stroke and bleeding risk scores. PMID: 32777794 [PubMed - in process]
Source: New Zealand Medical Journal - August 12, 2020 Category: General Medicine Tags: N Z Med J Source Type: research

Assessment of image quality and dose in contrast-enhanced head and neck CT angiography of New Zealand rabbit.
CONCLUSIONS: Low dose CTA of rabbits with 70 or 80 kVp is feasible in a 256-slice or a 64-slice CT scanner. The radiation dose from the 256-slice CTA was much lower than that from the 64-slice CTA with comparable SNR and CNR. The technique can be further applied in longitudinal monitoring of an animal stroke model in the future. PMID: 32597826 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - July 1, 2020 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Bilateral vertebral artery dissection and cerebellar stroke: a rare complication of massage.
We describe the case of a 39-year-old male, who presented to our emergency department after a one-day history of headache and vomiting, with associated sudden onset posterior neck pain and cerebellar signs following a massage. Computed tomography angiogram and brain demonstrated bilateral vertebral artery dissection and cerebellar stroke. He was admitted to hospital for monitoring and conservative management with antiplatelet therapy, resulting in a good outcome. This is the first reported case of bilateral vertebral artery dissection and stroke to be associated with massage. This case also suggests, unlike many reports in...
Source: New Zealand Medical Journal - April 5, 2020 Category: General Medicine Tags: N Z Med J Source Type: research

Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke
This study investigated shortened dosage schedules of DDFPe in nonstandard posterior (NSTND) strokes following occlusions of the posterior cerebral arteries. DDFPe given at shortened schedules of 30 or 60-min injection intervals will reduce neurological deficits, percent stroke volume (%SV), and serum glutamate levels in NSTND ischemic strokes. New Zealand White rabbits (N = 26) were randomly placed into three groups: A (n = 9) controls given saline injections every 60 min, B (n = 9) 2 % DDFPe given IV every 30 min, and C (n = 8) DDFPe every 60 min. Injections began 1 h after embolization. Groups were subdivid...
Source: Molecular Neurobiology - July 13, 2017 Category: Neurology Source Type: research

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