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Changes in demographics, treatment and outcomes in a  consecutive cohort who underwent transcatheter aortic valve implantation between 2005 and 2020
CONCLUSION: Over our 15 years' experience, patient age remained unchanged but the patient risk profile became more favourable. Simplification of the TAVI procedure occurred in parallel with major improvement in outcomes and survival. Bleeding/vascular complications and the need for pacemaker implantation remain the Achilles' heel of TAVI.PMID:35212972 | DOI:10.1007/s12471-022-01662-2
Source: Netherlands Heart Journal - February 25, 2022 Category: Cardiology Authors: M J A G De Ronde-Tillmans R M Nuis J A Goudzwaard P A Cummins T W Hokken M P H Van Wiechen J F W Ooms J Daemen N M D A Van Mieghem F U S Mattace-Raso M J Lenzen P P T de Jaegere Source Type: research

Endovascular Thrombectomy in Young Patients With Stroke: A MR CLEAN Registry Study
CONCLUSIONS: Ten percent of patients with acute ischemic stroke undergoing endovascular thrombectomy were younger than 50. Cardioembolism and carotid dissection were common underlying causes in young patients. In one-third of cases, no cause was identified, indicating the need for more research on stroke cause in young patients. Young patients had better prognosis and lower risk of symptomatic intracranial hemorrhage than older patients.PMID:34872339 | DOI:10.1161/STROKEAHA.120.034033
Source: Atherosclerosis - December 7, 2021 Category: Cardiology Authors: Josje Brouwer Johanna A Smaal Bart J Emmer Inger R de Ridder Ido R van den Wijngaard Frank-Erik de Leeuw Jeannette Hofmeijer Wim H van Zwam Jasper M Martens Yvo B W E M Roos Charles B Majoie Robert J van Oostenbrugge Jonathan M Coutinho MR CLEAN Registry Source Type: research

Major threats to early safety after transcatheter aortic valve implantation in a  contemporary cohort of real-world patients
CONCLUSION: A variety of underlying mechanisms and causes form a wide spectrum of major threats affecting early safety in 11.7% of patients undergoing TAVI in a contemporary cohort of real-world patients.PMID:34724147 | DOI:10.1007/s12471-021-01638-8
Source: Netherlands Heart Journal - November 1, 2021 Category: Cardiology Authors: D J van Ginkel J Brouwer N D van Hemert A O Kraaijeveld B J W M Rensing M J Swaans L Timmers M Voskuil P R Stella J M Ten Berg Source Type: research

Antithrombotic therapy in high-risk patients  after percutaneous coronary intervention; study design, cohort profile and incidence of adverse events
CONCLUSION: The high risk for both bleeding and ischaemic events in this cohort of patients with multiple clinical risk factors illustrates the challenges that the cardiologist faces to make a balanced decision on the optimal treatment strategy. This cohort will serve to answer several future research questions about the optimal management of these patients on dual/triple antithrombotic therapy, and the possible value of a wide range of laboratory tests to guide these decisions.PMID:34468944 | DOI:10.1007/s12471-021-01606-2
Source: Netherlands Heart Journal - September 1, 2021 Category: Cardiology Authors: R H Olie P E J van der Meijden M J A Vries L Veenstra A W J van 't Hof J M Ten Berg Y M C Henskens H Ten Cate Source Type: research

Report on outcomes of valve-in-valve transcatheter aortic valve implantation and redo surgical aortic valve replacement in the Netherlands
CONCLUSION: Patients with degenerated aortic bioprostheses treated with ViV-TAVI or redo-SAVR have similar mortality and morbidity.PMID:34373997 | DOI:10.1007/s12471-021-01608-0
Source: Netherlands Heart Journal - August 10, 2021 Category: Cardiology Authors: G J van Steenbergen B van Straten K Y Lam D van Veghel L Dekker P A Tonino Source Type: research

Clinical consequences of consecutive self-expanding transcatheter heart valve iterations
CONCLUSIONS: TAVI with self-expanding valves was safe, and device iterations may result in a lower need for PPI. More-than-mild PVL seemed to occur less often with repositionable technology.PMID:33914259 | DOI:10.1007/s12471-021-01568-5
Source: Netherlands Heart Journal - April 29, 2021 Category: Cardiology Authors: H G Kroon L van Gils F Ziviello M P H van Wiechen J F W Ooms Z Rahhab N El Faquir A-M Maugenest J A Goudzwaard P Cummins M Lenzen I Kardys J Daemen F Mattace-Raso P P T de Jaegere N M Van Mieghem Source Type: research

Effect of anticoagulant therapy in COVID-19 patients
CONCLUSION: Analysis of the literature showed that there was insufficient evidence to answer our objective on the effect of anticoagulation on outcome in COVID-19 patients, especially due to the low scientific quality of the described studies. Randomised controlled studies are needed to answer this question.PMID:33861430 | DOI:10.1007/s12471-021-01574-7
Source: Netherlands Heart Journal - April 16, 2021 Category: Cardiology Authors: R G Tieleman F A Klok E Belfroid J Hoogervorst-Schilp I Schalkers C W Jansen H J Siebelink Source Type: research

The effects of ACE2 expression mediating pharmacotherapy in COVID-19  patients
CONCLUSION: Analysis of the literature demonstrated that there was insufficient evidence to answer our objective on the effect of ACE2 expression mediating pharmacotherapy on outcome in COVID-19 patients, especially due to the low scientific quality of the described studies. Randomised controlled studies are needed to answer this question.PMID:33860910 | DOI:10.1007/s12471-021-01573-8
Source: Netherlands Heart Journal - April 16, 2021 Category: Cardiology Authors: R R J van Kimmenade E Belfroid J Hoogervorst-Schilp H J Siebelink C W Janssen Y Pinto Source Type: research

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