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Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study
CONCLUSION: From 2000 to 2018, the use of PDE5 inhibitors increased 20-fold among Danish patients with IHD who were taking nitrates. A statistically significant association between concomitant use of these medications and cardiovascular adverse events could not be identified.PRIMARY FUNDING SOURCE: Ib Mogens Kristiansens Almene Fond and Helsefonden.PMID:35436155 | DOI:10.7326/M21-3445
Source: Annals of Internal Medicine - April 18, 2022 Category: Internal Medicine Authors: Anders Holt Paul Blanche Aksel Karl Georg Jensen Nina Nouhravesh Deepthi Rajan Mads Hashiba Jensen Mohammed El-Sheikh Anne-Marie Schjerning Morten Schou Gunnar Gislason Christian Torp-Pedersen Patricia McGettigan Morten Lamberts Source Type: research

Effect of Variation in Published Stroke Rates on the Net Clinical Benefit of Anticoagulation for Atrial Fibrillation.
Conclusion: Variation in published AF stroke rates for patients not receiving anticoagulant therapy results in multifold variation in the net clinical benefit of anticoagulation. Guidelines should better reflect the uncertainty in current thresholds of stroke risk score for recommending anticoagulation. Primary Funding Source: None. PMID: 30264130 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 25, 2018 Category: Internal Medicine Authors: Shah SJ, Eckman MH, Aspberg S, Go AS, Singer DE Tags: Ann Intern Med Source Type: research