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Total 6068 results found since Jan 2013.
Vasoprotective Effects of Hyperoside against Cerebral Ischemia/Reperfusion Injury in Rats: Activation of Large-Conductance Ca < sup > 2+ < /sup > -Activated K < sup > + < /sup > Channels
Neural Plast. 2023 Aug 14;2023:5545205. doi: 10.1155/2023/5545205. eCollection 2023.ABSTRACTHyperoside (Hyp), a kind of Chinese herbal medicine, exerts multiple therapeutic effects on many diseases. However, the role and mechanisms of Hyp in vascular pathophysiology in ischemic stroke need to be further established. The study aimed to investigate the role of (large-conductance Ca2+-activated K+) BK channels on the vasoprotection of Hyp against cerebral ischemia and reperfusion (I/R) injury in rats. The concentration gradient of Hyp was pretreated in both the middle cerebral artery occlusion and reperfusion model and oxygen...
Source: Neural Plasticity - August 23, 2023 Category: Neurology Authors: Wen-Ming Hong Yue-Wu Xie Meng-Yu Zhao Tian-Hang Yu Li-Na Wang Wan-Yan Xu Shen Gao Hua-Bao Cai Yan Guo Fang Zhang Source Type: research
CYP2C19 Loss-of-Function Variants Associated with Long-term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population
This study aims to determine whether CYP2C19 loss-of-function (LoF) variants were associated with long-term ischemic stroke risk in Chinese primary care patients treated with clopidogrel. Patients treated with clopidogrel were ascertained from a Chinese Electronic Medical Record linked with biobank for a retrospective cohort study. Their medical information was examined for the period from January 2018 to December 2021. Two CYP2C19 major loss of function variants (*2:rs4244285, *3: rs4986893) were genotyped. The clinical outcome was ischemic stroke event. Cox regression analysis was used to evaluate the association between...
Source: Clinical Pharmacology and Therapeutics - August 22, 2023 Category: Drugs & Pharmacology Authors: Peng Wu Ziqing Liu Zijian Tian Benrui Wu Jian Shao Qian Li Zhaoxu Geng Ying Pan Ke Lu Qiang Wang Tao Xu Kaixin Zhou Source Type: research
Factors related to dietary quality among older stroke high-risk population in Tianjin community, China: a multicenter study
Stroke is a common and frequently-occurring disease in older people. It has the characteristics of high morbidity, high mortality, high recurrence rate and high disability rate. Most stroke risk studies are ba...
Source: BMC Geriatrics - August 22, 2023 Category: Geriatrics Authors: Yumeng Gu, Decheng Gao, Xiaoshuang Xia, Juanjuan Xue, Dongliang Wang, Zhiqiang Wei, Xiaolin Tian and Xin Li Tags: Research Source Type: research
Association between alcohol consumption and risk of stroke among adults: results from a prospective cohort study in Chongqing, China
The incidence of stroke in China is increasing, along with a clear trend in the prevalence of risk factors. Alcohol consumption is also a risk factor for stroke. Many cohort studies have explored the relations...
Source: BMC Public Health - August 22, 2023 Category: Consumer Health News Authors: Xin Liu, Xianbin Ding, Fan Zhang, Liling Chen, Qinwen Luo, Meng Xiao, Xiang Liu, Yunyun Wu, Wenge Tang, Jingfu Qiu and Xiaojun Tang Tags: Research Source Type: research
