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Total 442 results found since Jan 2013.

Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Journal of Medicine and Life - May 11, 2023 Category: General Medicine Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research

Carbon dioxide flushing versus saline flushing of thoracic aortic stents (INTERCEPTevar): protocol for a multicentre pilot randomised controlled trial
Introduction Thoracic endovascular aortic repair (TEVAR) carries a 3%–6.1% stroke risk, including risk of ‘silent’ cerebral infarction (SCI). Stent-grafts are manufactured in room air and retain air. Instructions for use recommend saline flushing to ‘de-air’ the system prior to insertion, but substantial amounts of air are released when deploying them, potentially leading to downstream neuronal injury and SCI. Carbon dioxide (CO2) is more dense and more soluble in blood than air, without risk of bubble formation, so could be used in addition to saline to de-air stents. This pilot trial aims to...
Source: BMJ Open - April 27, 2023 Category: General Medicine Authors: Crockett, S., Hanna, L., Singh, A., Gunning, S., Nicholas, R., Bicknell, C., Hamady, M., Gable, D., Sallam, M., Modarai, B., Abisi, S., Lyons, O., Gibbs, R. Tags: Open access, Surgery Source Type: research

Limited sequence magnetic resonance imaging appears reasonable for the evaluation of stroke-like symptoms
N Z Med J. 2023 Apr 14;136(1573):120-123.ABSTRACTNil.PMID:37054463
Source: New Zealand Medical Journal - April 13, 2023 Category: General Medicine Authors: Rachel E Matthews Karim M Mahawish Source Type: research