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Source: Neurology
Condition: Ataxia

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Total 53 results found since Jan 2013.

Efficacy and safety of abobotulinumtoxinA in spastic lower limb: Randomized trial and extension
Conclusions: In chronic hemiparesis, single abobotulinumtoxinA (Dysport Ipsen) administration reduced muscle tone. Repeated administration over a year was well-tolerated and improved walking speed and likelihood of achieving community ambulation. Clinicaltrial.gov identifiers: NCT01249404, NCT01251367. Classification of evidence: The double-blind phase of this study provides Class I evidence that for adults with chronic spastic hemiparesis, a single abobotulinumtoxinA injection reduces lower extremity muscle tone.
Source: Neurology - November 27, 2017 Category: Neurology Authors: Gracies, J.-M., Esquenazi, A., Brashear, A., Banach, M., Kocer, S., Jech, R., Khatkova, S., Benetin, J., Vecchio, M., McAllister, P., Ilkowski, J., Ochudlo, S., Catus, F., Grandoulier, A. S., Vilain, C., Picaut, P., On behalf of the International Abobotul Tags: Gait disorders/ataxia, Botulinum toxin, All Clinical trials ARTICLE Source Type: research

Clinical Reasoning: Two see or not two see--Is it really double vision?
A 57-year-old right-handed woman presented to the emergency department with complaints of double vision and intractable nausea that began abruptly 2 days earlier. Her visual symptoms were characterized as seeing overlapping or separate horizontally or diagonally displaced objects. She had no history of headaches or stroke. Her cerebrovascular risk factors included hypertension, type II diabetes, coronary artery disease, and cigarette smoking. Her medications included clopidogrel, lisinopril, paroxetine, and oxycodone. Her family history was notable for late-onset ischemic heart disease in her parents with no first-degree r...
Source: Neurology - August 7, 2017 Category: Neurology Authors: Murphy, R. R., Al Sawaf, A., Rose, D. R., Goldstein, L. B., Smith, C. D. Tags: Clinical neurology examination, Diplopia (double vision), Visual fields, Visual processing, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

An Unusual Presentation of Varicella Zoster Virus with Acute Cerebellitis and SIADH without a rash. (P2.315)
Conclusions:This report illustrates an unusual presentation of acute VZV cerebellitis and encephalitis, without a rash. To our understanding, this shows for the first time, severe acute onset neurological sequelae due to VZV.Disclosure: Dr. Lubomski has nothing to disclose. Dr. Markus has nothing to disclose. Dr. Brown has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lubomski, M., Markus, R., Brown, L. Tags: HIV, HTLV-I, PML, Other Viral Infections, and CJD Source Type: research

A rare cause of stroke in young: PHACE syndrome (P1.253)
Conclusions:Neurocutaneous syndromes are typically diagnosed in childhood and can be a rare cause of stroke in young. Our patient suffered an ischemic stroke secondary to sequelae of undiagnosed PHACE syndrome. Early identification of neurocutaneous syndromes allows for proper surveillance, evaluation, and preventative education for development of complications.Disclosure: Dr. Fitzgerald has nothing to disclose. Dr. Chandra has nothing to disclose. Dr. Dannenbaum has nothing to disclose. Dr. Sharrief has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Fitzgerald, K., Chandra, S., Dannenbaum, M., Sharrief, A. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Analysis of Run Sheets of EMS Serving a Metropolitan Comprehensive Stroke Center (P1.268)
Conclusions:Patients with acute stroke transported by EMS have better quality metrics and higher chance of receiving acute treatment. EMS documented assessment allows for the diagnosis or stroke in general but cannot identify LVO because the assessment of cortical signs is very limited.Disclosure: Dr. Hussein has nothing to disclose. Dr. Kashyap has nothing to disclose. Dr. Erickson has nothing to disclose. Dr. Forsberg has nothing to disclose. Dr. Burnett has nothing to disclose. Dr. Stanfield has nothing to disclose. Dr. Wewerka has nothing to disclose. Dr. Terwilliger has nothing to disclose. Dr. Hanson has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Hussein, H., Kashyap, B., Erickson, L., Forsberg, A., Burnett, A., Stanfield, S., Wewerka, S., Terwilliger, A., Hanson, L. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research

A novel CABC1/ADCK3 mutation in Adult-onset cerebellar ataxia (P6.021)
Conclusions:This is the first report of a duplication mutation on ADCK3/CABC1 in a patient with adult-onset progressive ataxia, chronic motor tics and familial seizures. Further studies are needed to elucidate whether the gain of function or a duplication-induced loss of function play a role in the pathophysiology of this condition.Disclosure: Dr. Malgireddy has nothing to disclose. Dr. Thompson has nothing to disclose. Dr. Torres-Russotto has received pesonal compensation for activities with Abbvie, Allergan, the American Parkinson Disease Foundation (APDA), Lundbeck, Teva, Huntington Disease Society of America (HDSA), Pa...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Malgireddy, K., Thompson, R., Torres-Russotto, D. Tags: Movement Disorders: Tics, Tremor & amp;amp; Ataxia II Source Type: research

What factors predict Fitbit adherence in Stroke and Parkinson disease? (P6.029)
Conclusions:The strongest predictor of adherence to daily activity monitoring was level of medical co-morbidity. Other determinants of adherence were self-efficacy for managing conditions, e-Health literacy and pain. Age and level of disability did not affect daily use of small wireless monitors to track activity in stroke and PD.Disclosure: Dr. Schrader has nothing to disclose. Dr. Mentis has nothing to disclose. Dr. Phipps has nothing to disclose. Dr. Barr has nothing to disclose. Dr. Gruber-Baldini has nothing to disclose. Dr. Yarbrough has nothing to disclose. Dr. Von Coelln has nothing to disclose. Dr. Shulman has rec...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Schrader, K., Mentis, H., Phipps, M., Barr, E., Gruber-Baldini, A., Yarbrough, K., Von Coelln, F. R., Shulman, L. Tags: Movement Disorders: Tics, Tremor & amp;amp; Ataxia II Source Type: research

Paradoxical Embolism in the Setting of Inferior Vena Cava Filter Removal (P1.283)
Conclusions:Although clinically relevant events secondary to IVC filter migration and fracture are rare, they can be life-threatening. Care should be taken when choosing to place these devices, and alternative therapies should be considered when possible. They should be removed when no longer needed, as fracture rates are increased with longer dwell times. Up to half of complications can be avoided with retrieval within 3 months.Disclosure: Dr. Yost has nothing to disclose. Dr. Klaas has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Yost, M., Klaas, J. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Central positional vertigo (P6.045)
Conclusions:Migraine may be a benign cause of CPV, however, a broad spectrum of diseases including tumors, stroke, infections and neurodegenerative disorders may be responsible. Earlier detection of posterior fossa lesions is critical to improve the outcome. Moreover, central positional vertigo/nystagmus could be the very first manifestation of the underlying disease.Central positional nystagmus is often an unrecognized entity. In this series, 3 patients had isolated positional DBN and truncal ataxia as the initial neurologic abnormality, one of them with a CNS neoplasm. Diagnostic clues for central localization are: prese...
Source: Neurology - April 17, 2017 Category: Neurology Authors: De Schutter, D., Kattah, J. Tags: Neuro-opthalmology/Neuro-otology II Source Type: research

Hemorrhagic stroke following consumption of energy drink (P3.271)
Conclusions:Apart from high levels of caffeine, Red Line also contains multiple other compunds like B-Phenylethylamine hydrochloride, Yohimbine, Toothed club moss extract and 5-hydroxytryptophan. Many of these agents are known to have sympathomimetic activity of their own. There is limited awareness of the potential interactions between these agents, and their safety when combined with caffeine. The Red Line bottle recommends that people with hypertension not use it, but our patient had not read these instructions. In conclusion, intracranial hemorrhage must be added to the list of side effects associated with energy drink...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Venkatraman, A., Khawaja, A., Shapshak, A. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Acute ischemic stroke in a young female: a novel presentation of anti-GAD autoimmunity (P3.272)
Conclusions:Restricted diffusion, seen typically in ischemia, indicates cytotoxic oedema and irreversible cell damage. In this patient, we postulate a mechanism of severe CNS inflammation with cellular toxicity and small vessel vasculitis. Anti-GAD autoimmunity should be considered in young patients presenting with stroke-like episodes, particularly when accompanied by positive phenomenon.Disclosure: Dr. Neo has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Neo, X. S., Lee, K. E., Lee, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Improving Tremor Detection and Quantification with Automated Measurements of Stroke Energy (P3.014)
Conclusions:The DCTE feature reliably and precisely quantifies stroke energy associated with tremor severity, with no additional clinician or patient burden. DCTclock’s stroke energy measurement correlates with clinician judgment and can accurately distinguish ET from HC.Disclosure: Dr. Musicus has received personal compensation for activities with Aptec Group and Digital Cognition Technologies, Inc. Dr. Medlock has received personal compensation for activities with Digital Cognition Technologies, Inc. Dr. Oppenheim has received personal compensation for activities with Digital Cognition Technologies, Inc as Advisor....
Source: Neurology - April 17, 2017 Category: Neurology Authors: Musicus, B., Medlock, C., Oppenheim, A., Davis, R., Apetauerova, D., Leegwater-Kim, J., Palmer, E., Penney, D., Souillard-Mandar, W. Tags: Movement Disorders: Tics, Tremor & amp;amp; Ataxia I Source Type: research

Teaching NeuroImages: Superficial siderosis due to a dural cervical arteriovenous fistula
A 58-year-old man presented to our hospital with cerebellar ataxia, pyramidal signs, dysarthria, bilateral deafness, and cognitive impairment. These symptoms were consistent with superficial siderosis (SS) of the CNS, confirmed by MRI (figure A).1 Cerebral angiography showed a dural arteriovenous fistula perispinal and pontic with venous drainage in the left foramen C1-C2, fed by meningeal branches of the vertebral artery (figure, B). The fistulous point was clipped. SS of CNS is a rare disease resulting from hemosiderin deposition on the surface of the CNS and cranial nerves.2 At diagnosis, the etiology may...
Source: Neurology - February 19, 2017 Category: Neurology Authors: Madkouri, R., Grelat, M. Tags: All Cerebrovascular disease/Stroke, All Spinal Cord, Arteriovenous malformation, Subarachnoid hemorrhage RESIDENT AND FELLOW SECTION Source Type: research

Vessel wall MRI of an inflamed aneurysm with atherosclerosis in a patient with ischemic stroke
This report of a patient with ischemic stroke shows the association of a symptomatic inflamed aneurysm with atherosclerotic plaque on IVWM.
Source: Neurology - August 14, 2016 Category: Neurology Authors: de Havenon, A., Park, M., McNally, S. Tags: MRI, DWI, Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke NEUROIMAGES Source Type: research

Teaching Video NeuroImages: Thalamic infarct with pseudo-abducens and vertical gaze palsies and an unusual stroke mechanism
A 32-year-old man presented with confusion and diplopia. His examination showed complete vertical gaze palsy with relatively preserved vertical vestibulo-ocular reflexes, convergence nystagmus on attempted upgaze, alternating adducting hypertrophic skew deviation, limited right eye abduction with esotropia, and right limb ataxia (video on the Neurology® Web site at Neurology.org). MRI showed a left paramedian thalamic infarct (figure 1). Vertical gaze palsy results from damage to the rostral interstitial nucleus of the medial longitudinal fasciculus. The contralateral abduction limitation is consistent with pseudo-abdu...
Source: Neurology - August 7, 2016 Category: Neurology Authors: Khayambashi, S., Fridhandler, J. D., Teal, P., Barton, J. J. S., Mann, S. K. Tags: Diplopia (double vision), All Cerebrovascular disease/Stroke, Embolism RESIDENT AND FELLOW SECTION Source Type: research