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Model development and comparison of low hemorrhage-risk endoluminal patch thrombolytic treatment for ischemic stroke
A thrombus blocking flow in a blood vessel deprives the brain cells of oxygen resulting in ischemic stroke and paralysis [1]. Thrombolysis treatment can be used to unblock the vessel [2]. A high dose of thrombolytic agents (urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA)) is administered to dissolve the blocking thrombus in eligible patients who are within 4.5  h from stroke onset [3,4]. Typically, 10,000–60,000 IU/kg (
Source: Medical Engineering and Physics - August 31, 2018 Category: Biomedical Engineering Authors: Zhen Qin, Francesco Ciucci, Chi Hang Chon, John C.K. Kwok, David C.C. Lam Source Type: research

An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC
Pulmonary embolism (PE) is the third most common cause of death from cardiovascular disease, after heart attack and stroke [1]. Usually associated with deep vein thrombosis (DVT), pulmonary embolism occurs when a venous thrombus embolizes and passes through the inferior vena cava (IVC) to the pulmonary arteries. Emboli occluding blood flow to one or both lungs can lead to impaired oxygenation, heart strain, and death [2].
Source: Medical Engineering and Physics - February 24, 2018 Category: Biomedical Engineering Authors: Elisabetta Tedaldi, Chiara Montanari, Kenneth I. Aycock, Francesco Sturla, Alberto Redaelli, Keefe B. Manning Source Type: research

Mechanical behavior of rf-treated thrombus in mechanical thrombectomy
Stroke is the second leading cause of death with 6.7 million deaths per year [1]. Among all stroke cases, ischemic stroke accounts for 87% [2]. Ischemic stroke occurs when a thrombus or an embolus occludes a cerebral vessel, interrupting the blood flow.
Source: Medical Engineering and Physics - July 5, 2017 Category: Biomedical Engineering Authors: Chi Hang Chon, Zhen Qin, John CK Kwok, David CC Lam Source Type: research