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Lipid Droplet Protein PLIN1 Regulates Inflammatory Polarity in Human Macrophages and is Involved in Atherosclerotic Plaque Development by Promoting Stable Lipid Storage
CONCLUSION: There was a relationship between macrophage polarity, cytosolic LD size, and PLIN1/PLIN2 expression levels. PLIN2 was mainly expressed in arterial plaques in symptomatic stroke patients, and associated with the inflammatory phenotype of human macrophages, while PLIN1 expression is closely associated with plaque stability and the anti-inflammatory phenotype.PMID:35662076 | DOI:10.5551/jat.63153
Source: Journal of Atherosclerosis and Thrombosis - June 6, 2022 Category: Cardiology Authors: Kyu Yong Cho Hideaki Miyoshi Akinobu Nakamura Andrew S Greenberg Tatsuya Atsumi Source Type: research

Evidence-Based Carotid Interventions for Stroke Prevention: State-of-the-art Review.
Authors: Morris DR, Ayabe K, Inoue T, Sakai N, Bulbulia R, Halliday A, Goto S Abstract Carotid artery stenosis is responsible for between 10-20% of all ischaemic strokes. Interventions, such as carotid endarterectomy and carotid stenting, effectively reduce the risk of stroke in selected individuals. This review describes the history of carotid interventions, and summarises reliable evidence on the safety and efficacy of these interventions gained from large randomised clinical trials.Early trials comparing carotid endarterectomy to medical therapy alone in symptomatic patients, and asymptomatic patients, demonstra...
Source: Journal of Atherosclerosis and Thrombosis - March 8, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Expression of Vasohibin-1 in Human Carotid Atherosclerotic Plaque.
CONCLUSIONS: The VASH1 expression levels in atheroma reflect both enhanced neovascularization and the inflammatory burden. Therefore, the VASH1 level may be a novel biomarker for evaluating plaque instability in patients with carotid arteriosclerosis and predicting ischemic stroke. PMID: 25843115 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - April 9, 2015 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research