• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Living Without a Pulse: The Vascular Implications of Continuous-Flow Left Ventricular Assist Devices Advances in Mechanical Circulatory Support
Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher ordered animals with more complex, multichamber circulatory systems that generate higher pulse pressure compared with lower ordered animals. Yet despite years of such natural selection, the modern generation of continuous-flow left ventricular assist devices (CF-LVADs) that have been increasingly used for the last decade have created a unique physiology characterized by a nonpulsatile, nonlaminar blood flow profile with the absence of the usual large elastic artery Windkessel effect during diastole. Although outcomes and durability h...
Source: Circulation: Heart Failure - June 14, 2018 Category: Cardiology Authors: Purohit, S. N., Cornwell, W. K., Pal, J. D., Lindenfeld, J., Ambardekar, A. V. Tags: Translational Studies, Vascular Biology, Heart Failure, Cardiovascular Surgery, Transplantation Advances in Mechanical Circulatory Support Source Type: research

Watchful Waiting in Continuous-Flow Left Ventricular Assist Device Patients With Ongoing Hemolysis Is Associated With an Increased Risk for Cerebrovascular Accident or Death Original Articles
Conclusions— Hemolysis refractory to intensification of antithrombotic therapy identifies continuous-flow left ventricular assist device patients at major risk for CVA and death. Early device exchange should be considered to minimize these risks.
Source: Circulation: Heart Failure - May 9, 2016 Category: Cardiology Authors: Levin, A. P., Saeed, O., Willey, J. Z., Levin, C. J., Fried, J. A., Patel, S. R., Sims, D. B., Nguyen, J. D., Shin, J. J., Topkara, V. K., Colombo, P. C., Goldstein, D. J., Naka, Y., Takayama, H., Uriel, N., Jorde, U. P. Tags: Cardiovascular Surgery, Transplantation, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Relationship Between Anticoagulation Intensity and Thrombotic or Bleeding Outcomes Among Outpatients With Continuous-Flow Left Ventricular Assist Devices Original Articles
Conclusions— INR is inversely related to thrombotic events occurring outside of the hospital among patients supported with CF-LVADs. INR values <2.0 increase the rate of thrombotic events occurring outside of the hospital among patients supported with CF-LVADs.
Source: Circulation: Heart Failure - May 5, 2016 Category: Cardiology Authors: Nassif, M. E., LaRue, S. J., Raymer, D. S., Novak, E., Vader, J. M., Ewald, G. A., Gage, B. F. Tags: Heart Failure, Anticoagulants, Transplantation, Intracranial Hemorrhage, Ischemic Stroke Original Articles Source Type: research