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P76 Fate of incomplete reperfusion caused by multiple small occlusions or slow flow in eTICI 2b reperfusion grade: insights from the ESCAPE-NA1 trial
ConclusionThe majority of incomplete reperfusion caused by multiple small occlusions or slow flow was associated with new infarction on follow-up imaging. In half of these cases, distal occlusions (meniscus sign) were detected, which could be potential targets for intra-arterial thrombolysis.ReferencesKaesmacher J, Ospel JM, Meinel TR, et al. Thrombolysis un Cerebral Infarction 2b Reperfusions. Stroke. September 2020. Do you have any conflict of interest to declare?: No
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Cimflova, P., Singh, N., Kappelhof, M., Sehgal, A., Ospel, J., Bala, F., Almekhlafi, M., Tymianski, M., Hill, M., Goyal, M. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

E-192 Association of myeloperoxidase-DNA complexes and high mobility group box 1 protein with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage
High mobility group box 1 protein (HMGB1) serves as a key player in aseptic inflammation. Admission serum HMGB1 has been identified as a biomarker predictive of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage (aSAH). Released by leucocytes and platelets, HMGB1 induces neutrophils to release condensed chromatin and protein granules, termed neutrophil extracellular traps (NETs). Myeloperoxidase (MPO)-DNA complexes are one major NET biomarker and have been associated with arterial and venous thrombosis formation. The prevalence and role of MPO-DNA in aSAH remains to be determined.A post-hoc analysis of ...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Hendrix, P., Witsch, J., Spalart, V., Martinod, K., Schneider, H., Oertel, J., Geisel, J., Hemmer, S. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke
Conclusions 3D-SEM provides novel and potentially clinically relevant information on clot components and ultrastructure which may help to inform thrombolytic treatment and medical device design.
Source: Journal of NeuroInterventional Surgery - September 15, 2021 Category: Neurosurgery Authors: Mereuta, O. M., Fitzgerald, S., Christensen, T. A., Jaspersen, A. L., Dai, D., Abbasi, M., Puttappa, T., Kadirvel, R., Kallmes, D. F., Doyle, K. M., Brinjikji, W. Tags: Ischemic stroke Source Type: research

P-005 Clot spatial heterogeneity rather than histologic composition is related to FPE rate
ConclusionSPI is a useful measure of clot structural heterogeneity and could provide more insights to improve the thrombectomy outcome compared to clot compositions.Disclosures Y. Liu: None. W. Brinjikji: None. M. Abbasi: None. D. Dai: None. J. Arturo Larco: None. D. Kallmes: None. L. Savastano: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Liu, Y., Brinjikji, W., Abbasi, M., Dai, D., Arturo Larco, J., Kallmes, D., Savastano, L. Tags: Oral poster abstracts Source Type: research

Successful recanalization in acute basilar artery occlusion treated with endovascular therapy is independent of thrombus length
Conclusions Successful recanalization does not depend on thrombus length in patients with BAO treated with EVT. Recanalization can therefore be achieved despite high clot burden. Additionally, a high density of thrombi was a strong predictor of a favorable outcome.
Source: Journal of NeuroInterventional Surgery - October 13, 2017 Category: Neurosurgery Authors: Shu, L., Riedel, C., Meyne, J., Jansen, O., Jensen-Kondering, U. Tags: Ischemic stroke Source Type: research

E-019 Outcome of the Patients Presenting with Basilar Occlusions in a Busy Stroke Center Treated with new Generation Stent Retrievers
ConclusionAlthough the successful recanalization rate (TICI 2 b or higher) in basilar occlusions is high (18/23 (78.3%)), the mortality (10/23 (43%)) and morbidity with MRS ≥ 3 (5/23 (22%)) remains disappointingly high. In our study, good clinical outcome (MRS 0–2) was achieved in 30% (7/23) of patients, better than the natural course in basilar occlusions, which is encouraging. This group highlights the value of early presentation and a negative CT as strong predictors of a good outcome. The prognosis in patients with basilar occlusions with positive CT findings and unknown time of onset remain guarded.Disclosure...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Akhtar, I., Halpin, J., Holloway, W., Martin, C., Akhtar, N. Tags: Electronic poster abstracts Source Type: research

E-054 Correlation between Thrombus Density and Recanalization or Stroke Etiology in Acute Ischemic Stroke
ConclusionIn conclusion, our study found no relationship between thrombus attenuation and recanalization success or stroke etiology. While prior studies have suggested that higher attenuation is associated with good recanalization, our study could not find such a link.4 More studies are required to identify factors that predict successful recanalization in acute ischemic stroke patients.DisclosuresM. Jagani: None. W. Brinjikji: None. D. Kallmes: 1; C; ev3, MicroVention, Sequent, Codman. 2; C; ev3, Medtronic, Codman. 3; C; Microvention.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Jagani, M., Brinjikji, W., Kallmes, D. Tags: Electronic poster abstracts Source Type: research

P-013 Use of the Solitaire Device for Emergency Revascularization of the Superior Mesenteric Artery
ConclusionsThe techniques and equipment used for acute stroke intervention may be suitable for acute recanalization of peripheral vessels, under the right circumstances. As with many surgical interventions, a multidisciplinary approach may at times yield a novel and effective strategy for a difficult clinical problem.DisclosuresJ. Dalfino: None. A. Paul: None. J. Hnath: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Dalfino, J., Paul, A., Hnath, J. Tags: Oral poster abstracts Source Type: research

A novel model of large vessel ischemic stroke in rabbits: microcatheter occlusion of the posterior cerebral artery
Conclusions Image-guided microcatheter induction of PCA occlusion in rabbits can consistently produce time-dependent infarction of cortical and subcortical structures that is reliably detected by diffusion-weighted MRI, and thus may be a useful model for therapeutic studies in acute ischemic stroke.
Source: Journal of NeuroInterventional Surgery - April 13, 2015 Category: Neurosurgery Authors: English, J. D., Hetts, S. W., El-Ali, A., Kolli, P., Do, L., Wilson, M. W., Saeed, M. Tags: Basic science Source Type: research

O-006 Analysis of Screened Patients from the Penumbra THERAPY Trial: Correlations of Clot Length Assessed by Thin-Section CT in a Sequential Series of Acute Stroke Patients
Conclusion This analysis further supports the idea of measuring hyperdense thrombus by use of thin-section NCCT. Occlusion site is a key predictor of clot length, which may explain the relative ineffectiveness of IV rtPA in more proximal anterior circulation large vessels. These findings suggest a sizeable population who may benefit from a bridging approach. Disclosures D. Frei: 3; C; Penumbra Inc. 4; C; Penumbra Inc. D. Heck: None. A. Yoo: 1; C; National Institutes of Health, Penumbra Inc., Remedy Pharmaceuticals. D. Loy: None. H. Buell: 5; C; Penumbra Inc. S. Kamalian: 1; C; GE Healthcare, Department of Defense, CIMIT. ...
Source: Journal of NeuroInterventional Surgery - July 26, 2014 Category: Neurosurgery Authors: Frei, D., Heck, D., Yoo, A., Loy, D., Buell, H., Kamalian, S., Morais, L., Bitner, A., Meyer, D., Kuo, S., Bose, A., Sit, S. Tags: Oral abstracts Source Type: research

P-020 Emergent Carotid Artery Stenting with or without Intracranial Tandem Occlusion Lesions Following Carotid Endarterectomy
Conclusion Emergent endovascular evaluation in the setting of acute post CEA thrombosis is a safe and timely treatment option, with the benefit of detecting and treating embolic intracranial lesions. More investigation is necessary to define the role of immediate angiography and intervention in this rare surgical complication. Abstract P-020 Table 1Patient demographics AgeGender% Carotid stenosisSymptomaticCase 166M90NCase 273M80–99YCase 378M70YCase 459F80–99YCase 555M80–99NCase 680MUnknownUnknown Abstract P-020 Table 2Pre procedural metrics Time from CEA to symptoms (hrs)Time from last normal to throm...
Source: Journal of NeuroInterventional Surgery - July 26, 2014 Category: Neurosurgery Authors: Vargas, J., Zuckerman, S., Chaudry, I., Turner, R., Turk, A., Spiotta, A. Tags: Oral poster abstracts Source Type: research