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Validating Imaging Biomarkers of Cerebral Edema in Patients With Severe Ischemic Stroke
Background: There is no validated neuroimaging marker for quantifying brain edema. We sought to test whether magnetic resonance imaging (MRI)–based metrics would reliably change during the early subacute period in a manner consistent with edema and whether they would correlate with relevant clinical endpoints.Methods: Serial MRI studies from patients in the Echoplanar Imaging Thrombolytic Evaluation Trial with initial diffusion-weighted imaging (DWI) lesion volume>82 cm3 were analyzed. Two independent readers outlined the hemisphere and lateral ventricle on the involved side and calculated respective volumes at baseline...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2012 Category: Neurology Authors: Albert J. Yoo, Kevin N. Sheth, W. Taylor Kimberly, Zeshan A. Chaudhry, Jordan J. Elm, Sven Jacobson, Stephen M. Davis, Geoffrey A. Donnan, Gregory W. Albers, Barney J. Stern, R. Gilberto González Tags: Original Articles Source Type: research

Ulcerated Carotid Plaques with Ultrasonic Echolucency Are Causatively Associated with Thromboembolic Cerebrovascular Events
The presence of ulcerated carotid plaques is a risk factor for ischemic stroke, which is associated with thromboembolism. We evaluated the relationship between ulcerated carotid plaques and cerebrovascular events in patients with acute ischemic stroke or transient ischemic attack. We extracted 48 consecutive patients with ulcerated carotid plaques from a cohort of 1111 patients with acute ischemic stroke or transient ischemic attack. All patients were evaluated by carotid ultrasonography and diffusion-weighted magnetic resonance imaging. We defined thromboembolic events by excluding potential cardiac sources of embolism, s...
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2011 Category: Neurology Authors: Tomomi Nakamura, Yukiko Tsutsumi, Yuko Shimizu, Shinichiro Uchiyama Tags: Original Articles Source Type: research

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