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Specialty: Drugs & Pharmacology
Condition: Thrombosis
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Total 546 results found since Jan 2013.
Investigational drugs for ischemic stroke: what's in the clinical development pipeline for acute phase and prevention?
Expert Opin Investig Drugs. 2022 Apr 29. doi: 10.1080/13543784.2022.2072725. Online ahead of print.ABSTRACTINTRODUCTION: Stroke is a leading cause of disability and mortality and its burden expected to increase. The only approved drug for acute ischemic stroke is the intravenous thrombolytic alteplase. The risk of bleeding complications is one of the reasons for the undertreatment of eligible patients. Numerous drugs are currently being developed to improve safety-efficacy.AREAS COVERED: We reviewed literature from January 1st, 2000, to 15th January 2022 for the development and testing of novel drugs with the aim of target...
Source: Expert Opinion on Investigational Drugs - April 29, 2022 Category: Drugs & Pharmacology Authors: Maria Giulia Mosconi Maurizio Paciaroni Walter Ageno Source Type: research
Conversion From Intravenous Alteplase to Tenecteplase for Treatment of Acute Ischemic Stroke Across a Large Community Hospital Health System
CONCLUSION AND RELEVANCE: Conversion from alteplase to tenecteplase can be safely and effectively achieved at a large community hospital health system with differing levels of stroke certification. There were also additional cost savings and practical advantages including workflow benefits.PMID:36688289 | DOI:10.1177/10600280221149409
Source: The Annals of Pharmacotherapy - January 23, 2023 Category: Drugs & Pharmacology Authors: Erika Dittmar Thomas Wolfel Lourdes Menendez Jessilyn Pozo Maygret Ramirez Starlie C Belnap Felipe De Los Rios La Rosa Source Type: research
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO
CNS Neurol Disord Drug Targets. 2023 Feb 3. doi: 10.2174/1871527322666230203140805. Online ahead of print.ABSTRACTThe gut microbiome interacts with the brain bidirectionally through the microbiome-gut-brain axis, which plays a key role in regulating various nervous system pathophysiological processes. Trimethylamine N-oxide (TMAO) is produced by choline metabolism through intestinal microorganisms, which can cross the blood-brain barrier to act on the central nervous system. Previous studies have shown that elevated plasma TMAO concentrations increase the risk of major adverse cardiovascular events, but there are few studi...
Source: CNS and Neurological Disorders Drug Targets - February 6, 2023 Category: Drugs & Pharmacology Authors: Ruxin Tu Jian Xia Source Type: research
