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Novel approaches to anti-atherosclerotic therapy: Cell-based models and herbal preparations (Review of our own data).
Abstract Atherosclerosis is a chronic arterial disease characterized by vascular inflammation, accumulation of lipids in the arterial wall, and formation and growth of atherosclerotic plaques followed by ischemia. In subclinical atherosclerosis, cholesterol retention in subendothelial cells leads to induction of local inflammation, generation of foam cells and lesion formation, followed by a chain of other pathogenic events. Atherosclerotic progression can frequently be fatal, since plaque rupture may lead to thrombosis and acute events, such as myocardial infarction, stroke and sudden death. Traditional anti-athe...
Source: Current Drug Discovery Technologies - December 31, 2018 Category: Drugs & Pharmacology Authors: Orekhov AN, Grechko AV, Romanenko EB, Zhang D, Chistiakov DA Tags: Curr Drug Discov Technol Source Type: research