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Antibodies against HDL Components in Ischaemic Stroke and Coronary Artery Disease.
In this study, we investigated whether antibodies against HDL components had additional value to conventional cardiovascular risk factors for the diagnosis of ischaemic stroke (IS) and coronary artery disease (CAD). Cross-sectional study was conducted on 53 patients with IS, 51 with CAD and 55 healthy controls, and in vitro studies to validate findings of the clinical study. We determined serum immunoglobulin G (IgG) antibodies against HDL (aHDL), apolipoproteins (aApoA-I, aApoA-II and aApoC-I) and paraoxonase-1 (aPON1) as well as PON1 activity (PON1a), total antioxidant capacity and biomarkers of endothelial activation (s...
Source: Thrombosis and Haemostasis - May 3, 2018 Category: Hematology Authors: Batuca JR, Amaral MC, Favas C, Justino GC, Papoila AL, Ames PRJ, Alves JD Tags: Thromb Haemost Source Type: research