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The new oral anticoagulants in atrial fibrillation: Once daily or twice daily?
Abstract The new anticoagulants (NOACs) tested for prevention or treatment of venous thromboembolism (VTE), stroke prevention in atrial fibrillation (AF), and acute coronary syndromes (ACS) differ in bioavailability, metabolism, route of excretion and interaction with other drugs, but have remarkably similar pharmacokinetics, with very similar half lives. However the choice of dosing regimens in different clinical conditions has been different for the various NOACs, and has been established on the basis of widely different considerations, including the clinical setting (venous versus arterial thrombosis), the indi...
Source: Vascular Pharmacology - July 18, 2013 Category: Drugs & Pharmacology Authors: Renda G, De Caterina R Tags: Vascul Pharmacol Source Type: research