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Anticoagulation for Stroke Prevention in Older Adults with Atrial Fibrillation and Comorbidity: Current Evidence and Treatment Challenges.
Authors: Sabbag A, Yao X, Siontis KC, Noseworthy PA Abstract The burden of atrial fibrillation (AF) is projected to increase substantially over the next decade in parallel with the aging of the population. The increasing age, level of comorbidity, and polypharmacy will complicate the treatment of older adults with AF. For instance, advanced age and chronic kidney disease have been shown to increase the risk of both thromboembolism and bleeding in patients with AF. Frailty, recurrent falls and polypharmacy, while very common among elderly patients with AF, are often overlooked in the clinical decision making despite...
Source: Korean Circulation Journal - September 22, 2018 Category: Cardiology Tags: Korean Circ J Source Type: research

Weeping Heart: Regrowing Thrombus at Basal Left Ventricle in Acute Stroke.
Authors: Jung SM, Park YH, Lee SH, Lee SY, Park KP, Kim JH PMID: 32096365 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - February 27, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Left Atrial Appendages Occlusion: Current Status and Prospective.
This article aims to provide current available evidence on efficacy and safety of different LAAO devices and future prospective. PMID: 30073807 [PubMed]
Source: Korean Circulation Journal - August 5, 2018 Category: Cardiology Tags: Korean Circ J Source Type: research

Combined Use of Neutrophil to Lymphocyte Ratio and C-Reactive Protein Level to Predict Clinical Outcomes in Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention.
CONCLUSION: Elevated levels of both NLR and CRP are associated with increased risk of long-term mortality in AMI patients who have undergone PCI. PMID: 28567089 [PubMed - in process]
Source: Korean Circulation Journal - June 3, 2017 Category: Cardiology Tags: Korean Circ J Source Type: research

Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients.
Authors: Joung B Abstract Regulatory approvals of non-vitamin K antagonist oral anticoagulants (NOACs) have been based on large randomized phase III trials evaluating dabigatran, rivaroxaban, apixaban, or edoxaban relative to warfarin for atrial fibrillation (AF). The results of the trials showed that all NOACs were at least non-inferior to warfarin in the prevention of stroke/thromboembolism and showed lower rates of intracranial bleeding than those associated with warfarin. However, the trials were designed differently, varied in the inclusion/exclusion criteria, and used either one dose or a low/high dose of the...
Source: Korean Circulation Journal - November 26, 2017 Category: Cardiology Tags: Korean Circ J Source Type: research

Impact of Anticoagulation Intensity in Korean Patients with Atrial Fibrillation: Is It Different from Western Population?
CONCLUSIONS: Mean INR 1.6-2.6 was better than mean INR 2.0-3.0 for the prevention of thromboembolism and major bleeding. However, INR 1.6-2.6 and TTR ≥70% had similar clinical outcomes to INR 2.0-3.0 and TTR ≥70% in Korean patients with non-valvular AF. PMID: 31642215 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - October 25, 2019 Category: Cardiology Tags: Korean Circ J Source Type: research

Is It Safe to Preserve Left Atrial Appendage During Maze Procedure?
CONCLUSIONS: In this study, preservation of the LAA during the maze procedure resulted in better LA function than LAA occlusion, with similar rates of stroke.PMID:37525493 | DOI:10.4070/kcj.2023.0038
Source: Korean Circulation Journal - August 1, 2023 Category: Cardiology Authors: Kyungsub Song Woo Sung Jang Namhee Park Yun Seok Kim Jae Bum Kim Source Type: research

Systematic Review of Treatment for Trapped Thrombus in Patent Foramen Ovale.
CONCLUSION: This systematic review showed that surgery was associated with a lower overall incidence of post-treatment embolic events and a lower 60-day mortality in patients with trapped thrombus in a PFO. In patients without initial shock or arrest, thrombolysis was related with a higher 60-day mortality compared with surgery. PMID: 28955396 [PubMed]
Source: Korean Circulation Journal - September 29, 2017 Category: Cardiology Tags: Korean Circ J Source Type: research

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