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Atria-selective antiarrhythmic drugs in need of alliance partners
Publication date: Available online 3 May 2019Source: Pharmacological ResearchAuthor(s): Rémi Peyronnet, Ursula RavensAbstractAtria-selective antiarrhythmic drugs in need of alliance partnersGuideline-based treatment of atrial fibrillation (AF) comprises prevention of thromboembolism and stroke, as well as antiarrhythmic therapy by drugs, electrical rhythm conversion, ablation and surgical procedures. Conventional antiarrhythmic drugs are burdened with unwanted side effects including a propensity of triggering life-threatening ventricular fibrillation. In order to solve this therapeutic dilemma, ‘atria-selective’ antia...
Source: Pharmacological Research - May 4, 2019 Category: Drugs & Pharmacology Source Type: research

Hydrogen sulfide stabilizes atherosclerotic plaques in apolipoprotein E knockout mice
In conclusion, H2S exerts protective effects against atherogenesis at least partly by stabilizing atherosclerotic plaque.Graphical abstract
Source: Pharmacological Research - April 6, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of recombinant plasminogen activator timing on thrombolysis in a novel rat embolic stroke model
Publication date: Available online 30 March 2016 Source:Pharmacological Research Author(s): Yinzhong Ma, Li Li, Ziran Niu, Junke Song, Yihuang Lin, Huifang Zhang, Guanhua Du The treatment of acute ischemic stroke (AIS) using thrombolysis with recombinant tissue-plasminogen activator (rtPA, alteplase) is limited by its narrow time window and the risk of hemorrhage. Recombinant plasminogen activator (rPA, reteplase) has been used clinically on coronary artery thrombosis and acute myocardial infarction. It is necessary to induce strokes experimentally as a means of validating the rPA timing on patients with AIS. Howe...
Source: Pharmacological Research - March 30, 2016 Category: Drugs & Pharmacology Source Type: research