• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Platelets induce apoptosis via membrane-bound FasL
After tissue injury, both wound sealing and apoptosis contribute to restoration of tissue integrity and functionality. Although the role of platelets (PLTs) for wound closure and induction of regenerative processes is well established, the knowledge about their contribution to apoptosis is incomplete. Here, we show that PLTs present the death receptor Fas ligand (FasL) on their surface after activation. Activated PLTs as well as the isolated membrane fraction of activated PLTs but not of resting PLTs induced apoptosis in a dose-dependent manner in primary murine neuronal cells, human neuroblastoma cells, and mouse embryoni...
Source: Blood - September 17, 2015 Category: Hematology Authors: Schleicher, R. I., Reichenbach, F., Kraft, P., Kumar, A., Lescan, M., Todt, F., Gobel, K., Hilgendorf, I., Geisler, T., Bauer, A., Olbrich, M., Schaller, M., Wesselborg, S., O'Reilly, L., Meuth, S. G., Schulze-Osthoff, K., Gawaz, M., Li, X., Kleinschnitz, Tags: Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research