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Association between bisphosphonate use and stroke risk: a meta-analysis
ConclusionOur results suggest that bisphosphonate use is associated with a lower risk of stroke. However, the current evidence does not lead to a definite conclusion due to the borderline statistical significance and high between-study heterogeneity. Future studies, especially RCTs, are necessary to assess causality.
Source: Osteoporosis International - May 30, 2023 Category: Orthopaedics Source Type: research

Sickle cell bone disease and response to intravenous bisphosphonates in children
ConclusionChildren with SCD have the potential for extensive and early-onset bone morbidity. In this series, IV bisphosphonates were effective for bone pain analgesia and did not trigger sickle cell complications.
Source: Osteoporosis International - July 29, 2022 Category: Orthopaedics Source Type: research

Incident peptic ulcers and concomitant treatment of direct oral anticoagulants and oral bisphosphonates —a real-world cohort study
ConclusionBased on our results, concomitant use of oBP and DOAC is associated with a slight increase in the risk of peptic ulcers compared to either drug alone. The prescribing physician should weigh the slight increased risk of ulcer in concomitant users of oBP and DOAC with beneficial reductions in stroke and fractures.
Source: Osteoporosis International - January 26, 2022 Category: Orthopaedics Source Type: research

Osteoporosis and the long-term risk of peripheral artery disease: a population-based longitudinal follow-up study in Taiwan
ConclusionThis study found an increased long-term risk of PAD in both men and women with osteoporosis.Mini abstractOsteoporosis has been associated with increased risks of atherosclerotic diseases. However, the relationship between osteoporosis and peripheral artery disease remains uncertain. The present population-based longitudinal follow-up study showed that patients with osteoporosis are at an increased risk of developing peripheral artery disease.
Source: Osteoporosis International - January 12, 2022 Category: Orthopaedics Source Type: research

Gait speed and spasticity are independently associated with estimated failure load in the distal tibia after stroke: an HR-pQCT study
ConclusionThe paretic distal tibia showed more compromised vBMD, cortical area, cortical thickness, and estimated failure load than the non-paretic tibia. Gait speed and spasticity were independently associated with estimated failure load. As treatment programs focusing on these potentially modifiable stroke-related impairments are feasible to administer, future studies are needed to determine the efficacy of such intervention strategies for improving bone strength in individuals with chronic stroke.
Source: Osteoporosis International - October 12, 2021 Category: Orthopaedics Source Type: research

Association between body mass index and the risk of falls: a nationwide population-based study
ConclusionsObesity was associated with a greater risk of recurrent falls in women, whereas underweight seemed to be associated with a greater risk of falls in men.
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Relationship between bone strength index of the hemiparetic tibial diaphysis and muscle strength in people with chronic stroke: influence of muscle contraction type and speed
ConclusionsConcentric muscle power was more predictive of %SSD in p-SSI at the tibial diaphysis than other contraction types and may be an important target for intervention to promote bone health in people with chronic stroke.
Source: Osteoporosis International - November 7, 2020 Category: Orthopaedics Source Type: research

Factors associated with fracture after stroke and TIA: a long-term follow-up
ConclusionStroke was positively associated with fracture in patients<  80 years, while TIA was positively associated with fracture in patients ≥ 80 years and females. Dementia and analgesic therapy were also associated with fracture after either stroke or TIA.
Source: Osteoporosis International - July 9, 2020 Category: Orthopaedics Source Type: research

Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis?
We present a narrative review of the benefits versus risks of using MHT in the management of postmenopausal osteoporosis. Current literature suggests robust anti-fracture efficacy of MHT in patients unselected for low BMD, regardless of concomitant use with progestogens, but with limited evidence of persisting skeletal benefits following cessation of therapy. Side effects include cardiovascular events, thromboembolic disease, stroke and breast cancer, but the benefit-risk profile differs according to the use of opposed versus unopposed oestrogens, type of oestrogen/progestogen, dose and route of delivery and, for cardiovas...
Source: Osteoporosis International - July 7, 2020 Category: Orthopaedics Source Type: research

Blindness increases the risk for hip fracture and vertebral fracture but not the risk for distal radius fracture: a longitudinal follow-up study using a national sample cohort
ConclusionThe risks for hip fracture and vertebral fracture were significantly higher in the blindness group. However, the risk for distal radius fracture was not related to visual impairment including blindness.
Source: Osteoporosis International - July 5, 2020 Category: Orthopaedics Source Type: research

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