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Source: Science Signaling
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Total 6 results found since Jan 2013.
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke
Sci Signal. 2023 Jun 6;16(788):eadd6364. doi: 10.1126/scisignal.add6364. Epub 2023 Jun 6.ABSTRACTBrain swelling causes morbidity and mortality in various brain injuries and diseases but lacks effective treatments. Brain swelling is linked to the influx of water into perivascular astrocytes through channels called aquaporins. Water accumulation in astrocytes increases their volume, which contributes to brain swelling. Using a mouse model of severe ischemic stroke, we identified a potentially targetable mechanism that promoted the cell surface localization of aquaporin 4 (AQP4) in perivascular astrocytic endfeet, which compl...
Source: Science Signaling - June 6, 2023 Category: Biomedical Science Authors: Jesse A Stokum Bosung Shim Serban Negoita Natalya Tsymbalyuk Orest Tsymbalyuk Svetlana Ivanova Kaspar Keledjian Joseph Bryan Mordecai P Blaustein Ruchira M Jha Kristopher T Kahle Volodymyr Gerzanich J Marc Simard Source Type: research
