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The Spot Sign and Intraventricular Hemorrhage are Associated with Baseline Coagulopathy and Outcome in Intracerebral Hemorrhage
ConclusionsThe spot sign and IVH are associated with specific hematoma characteristics, such as size and location, but are related differently to coagulation status and clinical course. A combined analysis of the spot sign and IVH can improve the understanding of pathophysiology and risk stratification after ICH.
Source: Neurocritical Care - June 28, 2022 Category: Neurology Source Type: research

Weaning Outcomes in Patients with Brain Injury
ConclusionsPatients with acute brain injury, compared with patients without brain injury, present higher odds of undergoing unplanned extubated after weaning was started, lower odds of being extubated after the first attempt, and a higher risk of reintubation.
Source: Neurocritical Care - September 1, 2022 Category: Neurology Source Type: research

Association Between Hyperacute Blood Pressure Variability and Hematoma Expansion After Intracerebral Hemorrhage: Secondary Analysis of the FAST-MAG Database
ConclusionsHigher BPV was not found to be associated with occurrence of HE in the hyperacute or the acute period of spontaneous ICH. Further study is needed to determine the relationship.
Source: Neurocritical Care - December 5, 2022 Category: Neurology Source Type: research

Risk Factors for Anticoagulant-Associated Intracranial Hemorrhage: A Systematic Review and Meta-analysis
Conclusions This study informs risk prediction for anticoagulant-associated intracranial hemorrhage and informs guidelines for intracranial hemorrhage prevention and future research.
Source: Neurocritical Care - January 20, 2023 Category: Neurology Source Type: research

Neuromonitoring During ECMO Support in Children
AbstractExtracorporeal membrane oxygenation is a potentially lifesaving intervention for children with severe cardiac or respiratory failure. It is used with increasing frequency and in increasingly more complex and severe diseases. Neurological injuries are important causes of morbidity and mortality in children treated with extracorporeal membrane oxygenation and include ischemic stroke, intracranial hemorrhage, hypoxic-ischemic injury, and seizures. In this review, we discuss the epidemiology and pathophysiology of neurological injury in patients supported with extracorporeal membrane oxygenation, and we review the curr...
Source: Neurocritical Care - January 31, 2023 Category: Neurology Source Type: research

Adherence to Established Blood Pressure Targets and Associated Complications in Patients Presenting with Acute Intracerebral Hemorrhage
ConclusionsIn individuals with nontraumatic/nonaneurysmal ICH, SBP measurements were observed to be  <  140 mm Hg for >  50% of the initial 48 h following admission. Hypotension and relative SBP reduction >  20% were also independent predictors of renal adverse events. SBP reduction >  20% was also an independent predictor of brain ischemia. These data indicate that intensive SBP reduction following ICH predispose patients to secondary organ injury that may impact long-term outcomes. Our data suggest that a more modest lowering of the SBP within 48 h, as recommended in the mos t recent guidel...
Source: Neurocritical Care - February 14, 2023 Category: Neurology Source Type: research

Heart Rate Variability in Patients with Spontaneous Intracerebral Hemorrhage and its Relationship with Clinical Outcomes
ConclusionsHRV values were impaired significantly within 14  days after ICH. Furthermore, HRV indices measured 10–14 days after ICH were independently associated with 3-month outcomes.
Source: Neurocritical Care - March 29, 2023 Category: Neurology Source Type: research

Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study
ConclusionsIn patients with ABI, hypoxemia and mild/moderate hyperoxemia were relatively frequent. Hypoxemia and hyperoxemia during ICU stay  may influence in-hospital mortality. However, the small number of oxygen values collected represents a major limitation of the study.
Source: Neurocritical Care - June 15, 2023 Category: Neurology Source Type: research

Resolution of Cerebral Inflammation Following Subarachnoid Hemorrhage
ConclusionsBy the herein presented molecular and histological data we provide an important indication for an incomplete resolution of inflammation within the brain parenchyma after SAH. Inflammatory resolution and the return to tissue homeostasis represent an important contribution to the disease ’s pathology influencing the impact on brain damage and outcome after SAH. Therefore, we consider a novel complementary or even superior therapeutic approach that should be carefully rethought in the management of cerebral inflammation after SAH. An acceleration of the resolution phase at the cell ular and molecular levels could...
Source: Neurocritical Care - June 22, 2023 Category: Neurology Source Type: research

The Influence of Body Mass Index on Outcomes in Patients Undergoing Mechanical Thrombectomy for Anterior Circulation Large Vessel Occlusion: Institutional Experience and Meta-analysis
ConclusionsObesity is not associated with favorable outcomes in patients undergoing MT for LVO.
Source: Neurocritical Care - July 27, 2023 Category: Neurology Source Type: research

Thematic Analysis of Psychosocial Stressors and Adaptive Coping Strategies Among Informal Caregivers of Patients Surviving ICU Admission for Coma
ConclusionsIn response to substantial stressors, family caregivers of patients with SABI attempted to enact various psychological and behavioral coping strategies. They described avoidance and distraction as less helpful than other coping strategies but had difficulty engaging in alternative strategies because of their emotional distress. These findings can directly inform the development of additional resources to mitigate the long-term impact of acute psychological distress among this caregiver population.
Source: Neurocritical Care - July 31, 2023 Category: Neurology Source Type: research

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Hospital Course, Confounders, and Medications
This article outlines the process of the development of common data elements for hospital course, confounders, and medications to streamline definitions and variables to collect for clinical studies of DoC.
Source: Neurocritical Care - August 23, 2023 Category: Neurology Source Type: research

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