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Stroke volume guided resuscitation in severe sepsis and septic shock improves outcomes
To determine whether stroke volume (SV) guided fluid resuscitation in patients with severe sepsis and septic shock alters Intensive Care Unit (ICU) fluid balance and secondary outcomes, this retrospective cohort study evaluated consecutive patients admitted to an ICU with the primary diagnosis of severe sepsis or septic shock. Cohorts were based on fluid resuscitation guided by changes in SV or by usual care (UC). The SV group comprised 100 patients, with 91 patients in the UC group. Net fluid balance for the ICU stay was lower in the SV group (1.77L) than in the UC group (5.36L) (p=0.022).
Source: Journal of Critical Care - June 28, 2017 Category: Intensive Care Authors: Heath E. Latham, Charles D. Bengtson, Lewis Satterwhite, Mindy Stites, Dipti P. Subramaniam, G. John Chen, Steven Q. Simpson Source Type: research

Effect of acute endotoxemia on analog estimates of mean systemic pressure
Abstract: Dynamic estimates of mean systemic pressure based on a Guytonian analog model (Pmsa) appear accurate under baseline conditions but may not remain so during septic shock because blood volume distribution and resistances between arterial and venous beds may change. Thus, we examined the effect of acute endotoxemia on the ability of Pmsa, estimated from steady-state cardiac output, right atrial pressure, and mean arterial pressure, to reflect our previously validated instantaneous venous return measure of mean systemic pressure (Pmsi), derived from beat-to-beat measures of right ventricular stroke volume and right a...
Source: Journal of Critical Care - June 3, 2013 Category: Intensive Care Authors: Jae Myeong Lee, Olufunmilayo Ogundele, Francis Pike, Michael R. Pinsky Tags: Electronic Articles Source Type: research