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Nitrone-based Therapeutics for Neurodegenerative Diseases. Their use alone or in Combination with Lanthionines.
Abstract The possibility of free radical reactions occurring in biological processes led to the development and employment of novel methods and techniques focused on determining their existence and importance in normal and pathological conditions. For this reason the use of Nitrones for spin trapping free radicals came into widespread use in the 1970s and 1980s when surprisingly the first evidence of their potent biological properties was first noted. Since then wide-spread exploration and demonstration of the potent biological properties of phenyl-tert-butylnitrone (PBN) and derivatives were shown in preclinical ...
Source: Free Radical Biology and Medicine - February 15, 2013 Category: Biology Authors: Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA Tags: Free Radic Biol Med Source Type: research