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Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder.
Abstract Matrix metalloproteinases (MMPs) play a key role in several diseases such as rheumatoid arthritis, HIV-associated neurological diseases (HAND), multiple sclerosis, osteoporosis, stroke, Alzheimer's disease, certain viral infections of the central nervous system, cancer, and hepatitis C virus. MMPs have been explained with regards to extracellular matrix remodeling, which occurs throughout life and ranges from tissue morphogenesis to wound healing in various processes. MMP are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). Matrix metalloproteases act as an interface between host's...
Source: Gene - February 26, 2019 Category: Genetics & Stem Cells Authors: Singh H, Nain S, Krishnaraj A, Lata S, Dhole TN Tags: Gene Source Type: research

New recommendations aim to improve safety of pain-relieving spinal steroid injections
More and more people are seeking injections of anti-inflammatory steroid medications for back and neck pain. In 2011, the last year for which complete information is available, doctors pushed the plunger on 2.3 million steroid injections into the spine — and that’s just among people covered by Medicare. These injections deliver drugs that mimic the effects of two hormones, cortisone and hydrocortisone, to reduce inflammation and help relieve pain. When they work — they don’t always — such injections can bring profound relief. “If you are in severe pain with a ruptured spinal disc and you get a stero...
Source: New Harvard Health Information - May 7, 2015 Category: Consumer Health News Authors: Daniel Pendick Tags: Back Pain Drugs and Supplements anti-inflammatory steroid medications spinal injections spine steroid injections Source Type: news