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Assessment of potential cardiovascular risks of methylphenidate in comparison with sibutramine: do we need a SCOUT (trial)?
Authors: Antel J, Albayrak O, Heusch G, Banaschewski T, Hebebrand J Abstract With the recent approval of methylphenidate (MPH) for treating attention-deficit/hyperactivity disorder (ADHD) in adults, the number of patients exposed will increase tremendously. The ongoing debate on the cardiovascular safety of MPH has triggered two large retrospective cohort studies in children and adolescents as well as in young to middle-aged adults. These studies looked into serious cardiovascular events (sudden cardiac death, acute myocardial infarction and stroke) as primary endpoints and concluded that MPH was safe after a mean ...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 26, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Table of Contents
Abstract Long QT syndrome more likely in patients with HIV, hepatitis C Long‐term treatments for obesity yield results with lifestyle changes Interaction of valproic acid with two drugs Topiramate study signals possible treatment for cocaine dependence Adjunctive modafinil improves depression, lessens fatigue D‐cycloserine, exposure therapy promising for treating PTSD Gabapentin results bode well for alcohol treatment by MDs Vortioxetine shows efficacy in treating major depression Better trials needed for SSRIs in stroke recovery Drug Safety Communication
Source: The Brown University Psychopharmacology Update - February 12, 2014 Category: Psychiatry Source Type: research

Vascular Risk Factors and Cognitive Decline in a Population Sample.
We examined several vascular factors in relation to the rates of decline in 5 cognitive domains in a population-based cohort. In an age-stratified random sample (N=1982) aged 65+ years, we assessed at baseline the cognitive domains of attention, executive function, memory, language, and visuospatial function, and also vascular, inflammatory, and metabolic indices. Random effects models generated slopes of cognitive decline over the next 4 years; linear models identified vascular factors associated with these slopes, adjusting for demographics, baseline cognition, and potential interactions. Several vascular risk factors (h...
Source: Alzheimer Disease and Associated Disorders - October 16, 2013 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Out-of-pocket expenditure burdens in patients with cardiovascular conditions and psychological distress: a nationwide cross-sectional study
Conclusions: Our findings suggest the need for physicians to identify and manage SPD in patients with CVD conditions and for policymakers to find solutions to reduce the high out-of-pocket burdens among these patients.
Source: General Hospital Psychiatry - February 6, 2013 Category: Psychiatry Authors: Yasuyuki Okumura, Hiroto Ito Tags: Psychiatric-Medical Comorbidity Source Type: research

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