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Revascularisation plus supervised exercise is superior to supervised exercise alone for the treatment of intermittent claudication
This study was a multicentre (10 sites), parallel-design randomised controlled trial of supervised exercise plus endovascular revascularisation versus supervised exercise alone for IC.4 Patients with IC and one or more stenotic lesions at the aortoiliac and/or femoropopliteal level amenable to endovascular therapy were eligible. Supervised exercise was provided 2–3 times per week for 30–45 min per session for 3 months and then continued...
Source: Evidence-Based Medicine - May 22, 2016 Category: Internal Medicine Authors: Vemulapalli, S. Tags: Clinical trials (epidemiology), Drugs: cardiovascular system, Stroke, Interventional cardiology, Radiology, Clinical diagnostic tests Therapeutics/Prevention Source Type: research

Invasive revascularisation in patients with moderate intermittent claudication provides a significant improvement in quality of life compared with conservative treatment
Commentary on: Nordanstig J, Taft C, Hensäter M, et al. Improved quality of life after 1 year with an invasive versus a noninvasive treatment strategy in claudicants: one-year results of the Invasive Revascularization or Not in Intermittent Claudication (IRONIC) Trial. Circulation 2014;130:939–47 . Context In cases of severe intermittent claudication (IC), successful revascularisation provides significant symptomatic improvement. In cases of mild IC, revascularisation has exceedingly high risks. The choice between invasive revascularisation and non-invasive treatments for moderate severity IC is often diffi...
Source: Evidence-Based Medicine - May 22, 2015 Category: Internal Medicine Authors: Kurklinsky, A. K. Tags: Epidemiologic studies, Pain (neurology), Stroke Therapeutics/Prevention Source Type: research

Ramipril improves walking times and quality of life in patients with stable intermittent claudication
Commentary on: Ahimastos AA, Walker PJ, Askew C, et al.. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA 2013;309:453–60. Context Intermittent claudication (IC) is a common condition that may be associated with significant disability and reduction in quality of life. Pharmacological options for the treatment of the symptoms of this condition are very limited. Naftidrofuryl oxalate is recommended in the National Institute for Health and Care Excellence (NICE) guidelines,1 and while this has been sho...
Source: Evidence-Based Medicine - January 22, 2014 Category: Internal Medicine Authors: Brittenden, J. Tags: Health policy, Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Health service research Therapeutics Source Type: research