• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

European Stroke Organisation (ESO) guidelines for the management of temperature in patients with acute ischemic stroke
ConclusionsThe currently available data about the management of temperature in patients with acute ischemic stroke are limited, and the strengths of the recommendations are therefore weak. We call for new randomized controlled trials as well as recruitment of eligible patients to ongoing randomized controlled trials to allow for better‐informed recommendations in the future.
Source: International Journal of Stroke - July 1, 2015 Category: Neurology Authors: George Ntaios, Tomasz Dziedzic, Patrik Michel, Vasileios Papavasileiou, Jesper Petersson, Dimitre Staykov, Brenda Thomas, Thorsten Steiner, Tags: Guidelines Source Type: research

Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema
Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic thrombolysis for acute ischemic stroke. To understand the paradox of injury caused by treatment, we first emphasize the phenomenon in which recanalization of an occluded artery does not lead to tissue reperfusion. Additionally, no‐reflow after recanalization may be due to injury of the neurovascular unit, distal microthrombosis, or both, and certainly worsens outcome. We examine the mechanism of molecular and subcellular damage in the...
Source: International Journal of Stroke - January 19, 2015 Category: Neurology Authors: Jilin Bai, Patrick D. Lyden Tags: Review Source Type: research

Hypothermia and atrial fibrillation
Source: International Journal of Stroke - June 9, 2014 Category: Neurology Authors: Geoffrey A. Donnan Tags: Editorial Source Type: research

EuroHYP‐1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke
DiscussionWith 750 patients per intervention group, this trial has 90% power to detect 7% absolute improvement at the 5% significance level. The full trial protocol is available at http://www.eurohyp1.eu. ClinicalTrials.gov Identifier: NCT01833312.
Source: International Journal of Stroke - May 15, 2014 Category: Neurology Authors: H. Bart Worp, Malcolm R. Macleod, Philip M. W. Bath, Jacques Demotes, Isabelle Durand‐Zaleski, Bernd Gebhardt, Christian Gluud, Rainer Kollmar, Derk W. Krieger, Kennedy R. Lees, Carlos Molina, Joan Montaner, Risto O. Roine, Jesper Petersson, Dimitre Sta Tags: Protocols Source Type: research

Targeted temperature management after intracerebral hemorrhage (TTM‐ICH): methodology of a prospective randomized clinical trial
ConclusionMore research of novel therapies to improve outcomes after intracerebral hemorrhage is desperately needed. The results of the targeted temperature management after intracerebral hemorrhage clinical trial may provide additional information on the applicability of targeted temperature management after intracerebral hemorrhage.
Source: International Journal of Stroke - January 23, 2014 Category: Neurology Authors: Fred Rincon, David P. Friedman, Rodney Bell, Stephan A. Mayer, Paul F. Bray Tags: Protocols Source Type: research

Hypothermia protects human neurons
ConclusionWe conclude that hypothermia protects stem cell‐derived human neurons against insults relevant to stroke over a clinically relevant time frame. Protection against H2O2‐induced injury and combined oxygen and glucose deprivation but not against oxygen deprivation alone suggests an interaction in which protection benefits from reduction in available glucose under some but not all circumstances.
Source: International Journal of Stroke - January 3, 2014 Category: Neurology Authors: Ana Antonic, Mirella Dottori, Jessie Leung, Kate Sidon, Peter E. Batchelor, William Wilson, Malcolm R. Macleod, David W. Howells Tags: Research Source Type: research

Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol
Therapeutic hypothermia improves neurological outcome after out‐of‐hospital cardiac arrest or neonatal hypoxic–ischemic injury. Although supported by preclinical evidence, therapeutic hypothermia for acute stroke remains under study. In the Intravascular Cooling in the Treatment of Stroke (ICTuS) trial, awake stroke patients were successfully cooled using an endovascular cooling catheter and a novel antishivering regimen. In the ICTuS‐L study, the combination of endovascular hypothermia and thrombolysis proved feasible; while hypothermia was associated with no increased risk of bleeding complications, there was an ...
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Patrick D. Lyden, Thomas M. Hemmen, James Grotta, Karen Rapp, Rema Raman Tags: Protocols Source Type: research

Short‐duration hypothermia after ischemic stroke prevents delayed intracranial pressure rise
ConclusionsWe saw major intracranial pressure elevation 24 h after stroke in two rat strains, even after small strokes. Short‐duration hypothermia prevented the intracranial pressure rise, an effect sustained for at least 18 h after rewarming. The findings have potentially important implications for design of future clinical trials.
Source: International Journal of Stroke - September 12, 2013 Category: Neurology Authors: L. A. Murtha, D. D. McLeod, S. K. McCann, D. Pepperall, S. Chung, C. R. Levi, M. B. Calford, N. J. Spratt Tags: Research Source Type: research

DEcompressive surgery Plus hypoTHermia for Space‐Occupying Stroke (DEPTH‐SOS): a protocol of a multicenter randomized controlled clinical trial and a literature review
DiscussionThe results of this trial will provide data on safety and feasibility of moderate hypothermia in addition to decompressive hemicraniectomy in malignant middle cerebral artery infarction. Furthermore, efficacy data on early mortality and long‐term functional outcome will be obtained, forming the basis of subsequent trials.
Source: International Journal of Stroke - June 20, 2013 Category: Neurology Authors: Hermann Neugebauer, Rainer Kollmar, Wolf‐Dirk Niesen, Julian Bösel, Hauke Schneider, Carsten Hobohm, Klaus Zweckberger, Peter U. Heuschmann, Peter D. Schellinger, Eric Jüttler, Tags: Protocol Source Type: research