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Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke
It has been suggested that medications can increase heat stroke (HS) susceptibility/severity. We investigated whether the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (INDO) increases HS severity in a rodent model. Core temperature (Tc) of male, C57BL/6J mice (n = 45) was monitored continuously, and mice were given a dose of INDO [low dose (LO) 1 mg/kg or high dose (HI) 5 mg/kg in flavored treat] or vehicle (flavored treat) before heating. HS animals were heated to 42.4°C and euthanized at three time points for histological, molecular, and metabolic analysis: onset of HS [maximal core temperature (Tc,Max)],...
Source: Journal of Applied Physiology - September 6, 2017 Category: Physiology Authors: Audet, G. N., Dineen, S. M., Stewart, D. A., Plamper, M. L., Pathmasiri, W. W., McRitchie, S. L., Sumner, S. J., Leon, L. R. Tags: RESEARCH ARTICLE Source Type: research

Recombinant interleukin-1{beta} dilates steelhead trout coronary microvessels: effect of temperature and role of the endothelium, nitric oxide and prostaglandins RESEARCH ARTICLE
Isabel A. S. F. Costa, Travis W. Hein, Christopher J. Secombes, and A. Kurt Gamperl Interleukin (IL)-1β is associated with hypotension and cardiovascular collapse in mammals during heat stroke, and the mRNA expression of this pro-inflammatory cytokine increases dramatically in the blood of Atlantic cod (Gadus morhua) at high temperatures. These data suggest that release of IL-1β at high temperatures negatively impacts fish cardiovascular function and could be a primary determinant of upper thermal tolerance in this taxa. Thus, we measured the concentration-dependent response of isolated steelhead trout (Oncorhync...
Source: Journal of Experimental Biology - July 22, 2015 Category: Biology Authors: Costa, I. A. S. F., Hein, T. W., Secombes, C. J., Gamperl, A. K. Tags: RESEARCH ARTICLE Source Type: research

Recombinant interleukin-1ss dilates steelhead trout coronary microvessels: effect of temperature and role of the endothelium, nitric oxide and prostaglandins RESEARCH ARTICLE
Isabel A. S. F. Costa, Travis W. Hein, Christopher J. Secombes, and A. Kurt GamperlInterleukin (IL)-1ß is associated with hypotension and cardiovascular collapse in mammals during heat stroke, and the mRNA expression of this pro-inflammatory cytokine increases dramatically in the blood of Atlantic cod (Gadus morhua, Linnaeus 1758) at high temperatures. These data suggest that IL-1ß release at high temperatures may negatively impact fish cardiovascular function, and be a primary determinant of upper thermal tolerance in this taxa. Thus, we measured the concentration-dependent response of isolated steelhead trout...
Source: Journal of Experimental Biology - May 29, 2015 Category: Biology Authors: Costa, I. A. S. F., Hein, T. W., Secombes, C. J., Gamperl, A. K. Tags: RESEARCH ARTICLE Source Type: research

Increased cytokine and chemokine gene expression in the CNS of mice during heat stroke recovery
Heat stroke (HS) is characterized by a systemic inflammatory response syndrome (SIRS) consisting of profound core temperature (Tc) changes in mice. Encephalopathy is common at HS collapse, but inflammatory changes occurring in the brain during the SIRS remain unidentified. We determined the association between inflammatory gene expression changes in the brain with Tc disturbances during HS recovery in mice. Gene expression changes of heat shock protein (HSP)72, heme oxygenase (hmox1), cytokines (IL-1β, IL-6, TNF-α), cyclooxygenase enzymes (COX-1, COX-2), chemokines (MCP-1, MIP-1α, MIP-1β, CX3CR1), and...
Source: AJP: Regulatory, Integrative and Comparative Physiology - November 1, 2013 Category: Physiology Authors: Biedenkapp, J. C., Leon, L. R. Tags: Call for Papers Source Type: research

Increased cytokine and chemokine gene expression in the CNS of mice during heat stroke recovery.
Abstract Heat stroke (HS) is characterized by a systemic inflammatory response syndrome (SIRS) consisting of profound core temperature (Tc) changes in mice. Encephalopathy is common at HS collapse, but inflammatory changes occurring in the brain during the SIRS remain unidentified. We determined the association between inflammatory gene expression changes in the brain with Tc disturbances during HS recovery in mice. Gene expression changes of heat shock protein (HSP)72, heme-oxygenase (hmox1), cytokines (IL-1β, IL-6, TNFα), cyclooxygenase enzymes (COX-1, COX-2), chemokines (MCP-1, MIP-1α, MIP-1β, CX3CR1), and ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 11, 2013 Category: Physiology Authors: Biedenkapp JC, Leon LR Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research