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Rediscovery of pioglitazone
Orv Hetil. 2023 Jul 2;164(26):1012-1019. doi: 10.1556/650.2023.32783. Print 2023 Jul 2.ABSTRACTIn the past decade and a half, clinical diabetology has undergone enormous development. New drug classes have appeared in everyday practice (GLP1 receptor agonists, SGLT2 inhibitors), which are able to improve the outcome of cardiovascular (macrovascular) complications in diabetes within a few years or even a few months, in contrast to the drugs used in previous large, prospective studies (UKPDS, VADT). The use of thiazolidinediones (including pioglitazone) unfortunately and significantly has declined in recent years, both intern...
Source: Orvosi Hetilap - July 2, 2023 Category: General Medicine Authors: Bence Pokoly Anik ó Somogyi Source Type: research

A h áromér-betegség kezelése a FAME-3 vizsgálat eredményeinek tükrében
Orv Hetil. 2022 Jun 26;163(26):1032-1036. doi: 10.1556/650.2022.32487. Print 2022 Jun 26.ABSTRACTPrevious randomized clinical studies have shown the superiority of coronary artery bypass grafting over percutaneous coronary intervention in the treatment of severe multivessel disease mainly because of a reduced need for repeat revascularization but, in some, a mortality benefit and reduced rate of myocardial infarction were shown among those undergoing surgery. The late breaker multicentric, randomized FAME (Fractional Flow Reserve Versus Angiography in Multivessel Evaluation)-3 study, involving 1500 patients, sought to dete...
Source: Orvosi Hetilap - July 27, 2022 Category: General Medicine Authors: Zsolt Pir óth G ábor Fülöp Bettina Csan ádi G éza Fontos P éter Andréka No émi Nyolczas Jen ő Szolnoky Source Type: research

Diagnosis of diabetic cardiac autonomic neuropathy.
Abstract Cardiac autonomic neuropathy (CAN) is a common complication in type 1 and 2 diabetes and is defined as the impairment of autonomic control of the cardiovascular system. CAN is strongly associated with increased mortality, and in some studies with morbidity of vascular complications, such as stroke, coronary artery disease and myocardial infarction. At the early stages, CAN can be subclinical and it becomes clinically evident as the disease progresses. Subclinically, the disease is defined by cardiovascular reflex testing, which may have prognostic implications. Clinically, the impairment in autonomic func...
Source: Orvosi Hetilap - August 27, 2019 Category: General Medicine Authors: Sztanek F, Jebelovszki É, Gaszner B, Zrínyi M, Páll D, Kempler P, Harangi M Tags: Orv Hetil Source Type: research

The labyrinth of residual risk: reduction of the remaining lipid and inflammation risk in the prevention of atherosclerosis.
Abstract Since cardiovascular diseases are the main cause of mortality worldwide, the reduction of their risk is a crucial point of present-day medicine. It has been proven unequivocally that the administration of various treatments has a favorable effect on the frequency of cardiovascular events and on the atherosclerosis leading to them. Although systematic and guideline-driven administration of these drugs has led to a decrease in the incidence and mortality of vascular events, the leading position of this group of diseases in mortality and morbidity has not changed. That is why medicine, besides keeping up act...
Source: Orvosi Hetilap - January 1, 2018 Category: General Medicine Authors: Márk L, Harangi M, Paragh G Tags: Orv Hetil Source Type: research

Short and long term prognosis of patients with myocardial infarction. Hungarian Myocardial Infarction Registry.
Conclusions: The rate of pre-hospital mortality was considerably high; 72.5% of 30 day mortality occurred before admission to hospital. Orv. Hetil., 2013, 154, 1297-1302. PMID: 23933608 [PubMed - in process]
Source: Orvosi Hetilap - August 1, 2013 Category: Journals (General) Authors: Jánosi A, Ofner P, Merkely B, Polgár P, Zámolyi K, Kiss RG, Edes I, Csapó K, Nagy L, Lupkovics G, Herceg B, Tomcsányi J, László Z, Vértes A, Simon J, Katona A, Juhász F, Bajkó F, Varjú I, Dinya E Tags: Orv Hetil Source Type: research