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Systemic Inflammation Is Associated With Neurologic Involvement in Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2
Conclusions Broad neurologic features were found in 12% patients with PIMS-TS. By 3-month follow-up, half of these surviving children had recovered fully without neurologic impairment. Significantly higher systemic inflammatory markers were identified in children with neurologic involvement and in those who had not recovered fully.
Source: Neurology Neuroimmunology and Neuroinflammation - April 13, 2021 Category: Neurology Authors: Sa, M., Mirza, L., Carter, M., Carlton Jones, L., Gowda, V., Handforth, J., Hedderly, T., Kenny, J., Lascelles, K., Lin, J.-P., Lumsden, D., McDougall, M., Miller, O., Rossor, T., Shivamurthy, V., Siddiqui, A., Singh, R., Tang, S., White, M., Byrne, S., L Tags: Childhood stroke, Encephalitis, Prognosis, All Neuropsychology/Behavior Article Source Type: research

Presentations and mechanisms of CNS disorders related to COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the coronavirus disease 2019 (COVID-19) pandemic. In addition to severe respiratory symptoms, there are a growing number of reports showing a wide range of CNS complications in patients with COVID-19. Here, we review the literature on these complications, ranging from nonspecific symptoms to necrotizing encephalopathies, encephalitis, myelitis, encephalomyelitis, endotheliitis, and stroke. We postulate that there are several different mechanisms involved in COVID-19–associated CNS dysfunction, particularly activation of inflammatory and thro...
Source: Neurology Neuroimmunology and Neuroinflammation - December 11, 2020 Category: Neurology Authors: Bodro, M., Compta, Y., Sanchez-Valle, R. Tags: Other cerebrovascular disease/ Stroke, Encephalitis, COVID-19 Views [amp ] Reviews Source Type: research