• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Poststroke Glycemic Variability Increased Recurrent Cardiovascular Events in Diabetic Patients
Type 2 diabetes mellitus is a well-known cause of coronary artery disease,(Klein, 1995; Turner et al., 1998) stroke(Lehto et al., 1996) and peripheral artery disease, and hyperglycemia due to poor glycemic control is strongly associated with diabetic complications.(Stratton et al., 2000) Besides, as time goes on, diabetes is accompanied by greater diurnal variation of serum glucose.(Egi et al., 2007) Glycemic variability seems to have more deleterious effects than sustained hyperglycemia on the development of diabetic complications.(Ceriello et al., 2008; Monnier et al., 2006; Su et al., 2011) The wide glycemic variability...
Source: Journal of Diabetes and Its Complications - December 2, 2016 Category: Endocrinology Authors: Jee-Eun Yoon, Jun-Sang Sunwoo, Ji Sun Kim, Hakjae Roh, Moo-Young Ahn, Hee-Yeon Woo, Kyung Bok Lee Source Type: research

Pioglitazone in patients with insulin resistance after ischemic stroke or transient ischemic attack: A comment on the IRIS trial
Pioglitazone, an antidiabetic drug, also exerts several cardiometabolic benefits including antioxidant, anti-inflammatory, antihypertensive, vasoprotective and hypolipidemic effects. These pioglitazone-related benefits have been observed in different patient populations such as those with prediabetes, non-alcoholic fatty liver disease and type 2 diabetes mellitus (T2DM). With regard to cardiovascular (CV) morbidity and mortality, there is conflicting evidence.Recently, the Insulin Resistance Intervention after Stroke (IRIS) trial reported a significant pioglitazone-induced decrease in CV morbidity in patients with insulin ...
Source: Journal of Diabetes and Its Complications - September 17, 2016 Category: Endocrinology Authors: Niki Katsiki, Dimitri P Mikhailidis Source Type: research

Plasma copeptin and functional outcome in patients with ischemic stroke and type 2 diabetes
In this study, we therefore evaluated the short-term prognostic value of early measurement of plasma copeptin levels in Chinese patients with type 2 diabetes mellitus (T2DM) and acute ischemic stroke (AIS).
Source: Journal of Diabetes and Its Complications - July 29, 2016 Category: Endocrinology Authors: Chi-Bo Wang, Miao Zong, Shi-Qing Lu, Zhuo Tian Source Type: research

Comparative risk for cardiovascular diseases of dipeptidyl peptidase-4 inhibitors vs. sulfonylureas in combination with metformin: Results of a two-phase study
The aim was to assess whether the use of additional data from the Disease Management Program (DMP) diabetes mellitus type 2 to minimize the potential for residual confounding will alter the estimated risk of either myocardial infarction, ischemic stroke or heart failure in patients with type 2 diabetes using sulfonylureas compared to dipeptidyl peptidase-4 (DPP-4) inhibitors in addition to metformin based on routine health care data.
Source: Journal of Diabetes and Its Complications - May 18, 2016 Category: Endocrinology Authors: Dirk Enders, Bianca Kollhorst, Susanne Engel, Roland Linder, Frank Verheyen, Iris Pigeot Source Type: research

Comparative Risk for Cardiovascular Diseases of Dipeptidyl Peptidase-4 Inhibitors vs. Sulfonylureas in Combination with Metformin: Results of a Two-Phase Study
The aim was to assess whether the use of additional data from the Disease Management Program (DMP) diabetes mellitus type 2 to minimize the potential for residual confounding will alter the estimated risk of either myocardial infarction, ischemic stroke or heart failure in patients with type 2 diabetes using sulfonylureas compared to dipeptidyl peptidase-4 (DPP-4) inhibitors in addition to metformin based on routine health care data.
Source: Journal of Diabetes and Its Complications - May 18, 2016 Category: Endocrinology Authors: Dirk Enders, Bianca Kollhorst, Susanne Engel, Roland Linder, Frank Verheyen, Iris Pigeot Source Type: research

The EMPA-REG Study: What has it told us? A Diabetologist’s Perspective
EMPA-REG (1) is the first study to conclusively demonstrate that a medication developed to reduce glycemia (2) in patients with type 2 diabetes mellitus (T2DM) decreases cardiovascular events. In 7020 T2DM patients with established cardiovascular (CV) disease, empagliflozin (pooled 10 and 25 mg/day doses) significantly reduced the primary MACE outcome (cardiovascular death, nonfatal MI, nonfatal stroke) by 14% compared to placebo (HR = 0.86, 95% CI = 0.74-0.99, P=0.04 for superiority). It is noteworthy that a striking disconnect was observed between the three MACE components; (i) for nonfatal MI, the HR (=0.87) decreased s...
Source: Journal of Diabetes and Its Complications - October 21, 2015 Category: Endocrinology Authors: Ralph A. DeFronzo Source Type: research

Detection of platelet microRNA expression in patients with diabetes mellitus with or without ischemic stroke
The objective of this study was to investigate the role of plasma and platelet microRNAs in the occurrence of ischemic stroke in patients with diabetes mellitus.
Source: Journal of Diabetes and Its Complications - April 28, 2014 Category: Endocrinology Authors: Xiaomei Duan, Qiong Zhan, Bingxin Song, Sian Zeng, Juan Zhou, Yuming Long, Jinfeng Lu, Zhibin Li, Mei Yuan, Xiaoping Chen, Qidong Yang, Jian Xia Source Type: research

Detection of platelet microRNA expression in patients with Diabetes Mellitus with and without Ischemic Stroke
Source: Journal of Diabetes and Its Complications - April 26, 2014 Category: Endocrinology Authors: Xiaomei Duan, Qiong Zhan, Bingxin Song, Sian Zeng, Juan Zhou, Yuming Long, Jinfeng Lu, Zhibin Li, Mei Yuan, Xiaoping Chen, Qidong Yang, Jian Xia Source Type: research

Detection of platelet microRNA expression in patients with diabetes mellitus with or without ischemic stroke
Source: Journal of Diabetes and Its Complications - April 26, 2014 Category: Endocrinology Authors: Xiaomei Duan, Qiong Zhan, Bingxin Song, Sian Zeng, Juan Zhou, Yuming Long, Jinfeng Lu, Zhibin Li, Mei Yuan, Xiaoping Chen, Qidong Yang, Jian Xia Source Type: research