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Bone Marrow Mononuclear Cell Transplantation Promotes Therapeutic Angiogenesis via Upregulation of the VEGF-VEGFR2 Signaling Pathway in a Rat Model of Vascular Dementia.
Abstract Bone marrow mononuclear cells (BMMNCs) are important for angiogenesis after stroke. We investigated the effects of BMMNCs on cognitive function, angiogenesis, and the vascular endothelial growth factor (VEGF)-VEGF receptor 2 (VEGFR2) signaling pathway in a rat model of vascular dementia. We transplanted BMMNCs into rats that had undergone permanent bilateral occlusion of the common carotid arteries (2VO) and observed their migration in vivo. On day 28, we assessed cognitive function with the Morris Water Maze test and examined vascular density and white matter damage within the corpus striatum by staining...
Source: Behavioural Brain Research - February 28, 2014 Category: Neurology Authors: Wang J, Fu X, Jiang C, Yu L, Wang M, Han W, Liu L, Wang J Tags: Behav Brain Res Source Type: research

Cerebral white matter hyperintensity predicts cardiovascular events in haemodialysis patients
ConclusionsThe present study indicates that the presence of WMHs is a novel predictor of cardiovascular events in HD patients, and that PVH is more closely associated with incident cardiovascular disease.
Source: Nephrology - September 19, 2013 Category: Urology & Nephrology Authors: Toshihide Naganuma, Yoshiaki Takemoto, Tetsuo Shoji, Hideaki Shima, Eiji Ishimura, Mikio Okamura, Tatsuya Nakatani Tags: Original Article Source Type: research

Decline in renal functioning is associated with longitudinal decline in global cognitive functioning, abstract reasoning and verbal memory
Conclusions Early detection of mild to moderate kidney disease is an important public health concern with regard to cognitive decline.
Source: Nephrology Dialysis Transplantation - July 10, 2013 Category: Transplant Surgery Authors: Davey, A., Elias, M. F., Robbins, M. A., Seliger, S. L., Dore, G. A. Tags: Chronic Kidney Disease Source Type: research

Cerebral White Matter Hyperintensity Predicts Cardiovascular Events in Hemodialysis Patients
ConclusionsThe present study indicates that the presence of WMHs is a novel predictor of cardiovascular events in HD patients, and that PVH is more closely associated with incident cardiovascular disease.
Source: Nephrology - June 21, 2013 Category: Urology & Nephrology Authors: Toshihide Naganuma, Yoshiaki Takemoto, Tetsuo Shoji, Hideaki Shima, Eiji Ishimura, Mikio Okamura, Tatsuya Nakatani Tags: Original Article Source Type: research

Kidney disease and cognitive function.
Abstract We provide a brief review of research on chronic kidney disease and cognitive performance, including dementia. We touch briefly on the literature relating end-stage-renal disease to cognitive function, but focus on studies of modest and moderate forms of chronic kidney disease (CKD) that precede dialysis and transplantation. We summarize previous reviews dealing with case control studies of patients but more fully examine community-based studies with large samples and necessary controls for demographic risk factors, cardiovascular variables, and other confounds such as depression. In addition we suggest p...
Source: Contributions to Nephrology - May 26, 2013 Category: Urology & Nephrology Authors: Elias MF, Dore GA, Davey A Tags: Contrib Nephrol Source Type: research

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