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Source: Atherosclerosis
Condition: Dementia
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Total 49 results found since Jan 2013.
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke
Circ Res. 2022 Apr 15;130(8):1167-1186. doi: 10.1161/CIRCRESAHA.121.319994. Epub 2022 Apr 14.ABSTRACTInflammation and immune mechanisms are crucially involved in the pathophysiology of the development, acute damage cascades, and chronic course after ischemic stroke. Atherosclerosis is an inflammatory disease, and, in addition to classical risk factors, maladaptive immune mechanisms lead to an increased risk of stroke. Accordingly, individuals with signs of inflammation or corresponding biomarkers have an increased risk of stroke. Anti-inflammatory drugs, such as IL (interleukin)-1β blockers, methotrexate, or colchicine, r...
Source: Atherosclerosis - April 14, 2022 Category: Cardiology Authors: Matthias Endres Maria A Moro Christian H Nolte Claudia Dames Marion S Buckwalter Andreas Meisel Source Type: research
Post-stroke Cognitive Impairment and Malnutrition in the Elderly (PCIME): study design and protocol
CONCLUSION: PCIME will enable us to assess the role of malnutrition in development of post stroke dementia. This study will help clinicians and researchers develop preventive measures to reduce the burden of stroke and dementia.PMID:34900843 | PMC:PMC8630267 | DOI:10.1007/s40200-021-00841-z
Source: Atherosclerosis - December 13, 2021 Category: Cardiology Authors: Zahra Vahabi M Reza Azarpazhooh Shima Raeesi Shahram Oveisgharan Farnaz Etesam Elahe Abedi-Taleb Rezvan Hashemi Source Type: research
Preventing post-stroke dementia. The MARCH Trial. Protocol and statistical analysis plan of a randomized clinical trial testing the safety and efficacy of Maraviroc in post-stroke cognitive impairment
CONCLUSIONS: The results of this work could lead to a novel, readily available, therapeutic avenue to reduce PSCI, and possibly other pathologies. This study will test safety and effectiveness of Maraviroc in limiting cognitive deterioration and/or post stroke cognitive impairment in patients with cerebral small vessel disease.SCHEDULE: First-patient first-visit was May 2021. Recruitment to complete in 2023, follow-up to complete in 2024.PMID:36082248 | PMC:PMC9446318 | DOI:10.1177/23969873221098857
Source: Atherosclerosis - September 9, 2022 Category: Cardiology Authors: Einor Ben Assayag Jeremy Molad Estelle Seyman Ofer Rotschild Ehud Zeltzer Udi Sadeh-Gonik Noa Bregman Aviva Alpernas Yahel Segal Dafna Ben Bashat Talya Nathan Muhamad Hawwari Oren Tene Hen Hallevi Source Type: research
Subclinical Vascular Composites Predict Clinical Cardiovascular Disease, Stroke, and Dementia: The Multi-Ethnic Study of Atherosclerosis (MESA)
CONCLUSIONS: Subclinical vascular composites of arteriosclerosis and atherosclerosis may be useful biomarkers to inform the vascular pathways contributing to events of CVD, CHD, stroke, and dementia.PMID:37205504 | PMC:PMC10187443 | DOI:10.1101/2023.05.01.23289364
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Timothy M Hughes Jordan Tanley Haiying Chen Christopher L Schaich Joseph Yeboah Mark A Espeland Joao A C Lima Bharath Ambale-Venkatesh Erin D Michos Jingzhong Ding Kathleen Hayden Ramon Casanova Suzanne Craft Stephen R Rapp Jos é A Luchsinger Annette L F Source Type: research
Cardiovascular disease, a major global burden: Epidemiology of stroke and ischemic heart disease in Japan
Glob Health Med. 2021 Dec 31;3(6):358-364. doi: 10.35772/ghm.2020.01113.ABSTRACTJapan ranks the highest globally, in terms of longevity. The average life expectancy was 81.4 years for men and 87.5 years for women in 2019. Such success in health is attributable to the substantial reduction in age-standardized mortality from cardiovascular diseases, especially stroke (136 per 105 in 1980 and 24 per 105 in 2015), when stroke mortality was the highest in the world between the 1960s and the 1990s. On the other hand, ischemic heart disease mortality was the lowest in the world between the 1960s and the 1980s and has continued to...
Source: Atherosclerosis - January 17, 2022 Category: Cardiology Authors: Hiroyasu Iso Source Type: research
Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment
Lancet Neurol. 2022 Feb 7:S1474-4422(21)00376-8. doi: 10.1016/S1474-4422(21)00376-8. Online ahead of print.ABSTRACTIntracranial atherosclerotic stenosis (ICAS) is one of the most frequent causes of stroke worldwide and confers one of the greatest risks of recurrent stroke compared with other causes of stroke. Asymptomatic ICAS is increasingly recognised as a risk factor for silent brain infarctions and dementia, magnifying the global burden of ICAS. Although ICAS is a lumen-based diagnosis, newer diagnostic imaging techniques, such as high-resolution MRI, might help to identify high-risk population subgroups to test interv...
Source: Atherosclerosis - February 10, 2022 Category: Cardiology Authors: Jose Gutierrez Tanya N Turan Brian L Hoh Marc I Chimowitz Source Type: research
Risk of Dementia Associated With Atrial Cardiopathy: The ARIC Study
Conclusions Atrial cardiopathy was significantly associated with an increased risk of dementia, with only a small percent mediation of the effect by AF or stroke.PMID:35946474 | DOI:10.1161/JAHA.121.025646
Source: Atherosclerosis - August 10, 2022 Category: Cardiology Authors: Michelle C Johansen Wendy Wang Michael Zhang David S Knopman Chiadi Ndumele Thomas H Mosley Elizabeth Selvin Amil M Shah Scott D Solomon Rebecca F Gottesman Lin Yee Chen Source Type: research
Antiplatelets and Vascular Dementia: A Systematic Review
J Aging Res. 2022 Sep 19;2022:9780067. doi: 10.1155/2022/9780067. eCollection 2022.ABSTRACTVascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology s...
Source: Atherosclerosis - October 17, 2022 Category: Cardiology Authors: Peter Alexander Shakthi Visagan Sara Jawhar Amogh Kare Noor Issa Reem Issa Abbas Jawhar Sneha Thomas Vasavi Gorantla Source Type: research
Comparison of Parameters for Assessment of Carotid Stiffness and Their Association with Carotid Atherosclerosis in Rural Australian Adults: A Pilot Study
J Clin Med. 2023 Apr 18;12(8):2935. doi: 10.3390/jcm12082935.ABSTRACTCarotid stiffness has been associated with the development and progression of carotid artery disease and is an independent factor for stroke and dementia. There has also been a lack of comparison of different ultrasound-derived carotid stiffness parameters and their association with carotid atherosclerosis. This pilot study aimed to investigate the associations between carotid stiffness parameters (derived via ultrasound echo tracking) and the presence of carotid plaques in Australian rural adults. In cross-sectional analyses, we assessed forty-six subjec...
Source: Atherosclerosis - April 28, 2023 Category: Cardiology Authors: Marjana Petrova Alex Gavino Yujie Li Craig S McLachlan Source Type: research
Association of ankle-brachial index with cognitive decline in patients with lacunar infarction
This study aimed to investigate the relationship of ankle-brachial pressure index (ABI) and brachial-ankle pulse wave velocity (baPWV) with cognitive function in patients with lacunar infarction. We included records of consecutive patients with their first-ever acute stroke and a diagnosis of lacunar infarction through magnetic resonance imaging (MRI) from July 1, 2011 to December 31, 2018. We excluded patients diagnosed with dementia, including strategic single-infarct dementia, before or after stroke onset. Moreover, we excluded patients with one or more microbleeds, severe white matter lesions, or severe medial temporal...
Source: Atherosclerosis - February 4, 2022 Category: Cardiology Authors: Masahiro Nakamori Hayato Matsushima Keisuke Tachiyama Yuki Hayashi Eiji Imamura Tatsuya Mizoue Shinichi Wakabayashi Source Type: research
Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia
CONCLUSIONS AND RELEVANCE: In this exploratory analysis of a US community-based cohort, several echocardiographic measures of lower LA function were significantly associated with an increased risk of subsequent dementia. Measures of LA size were not significantly associated with dementia risk. These findings suggest that impaired LA function may be a risk factor associated with dementia.PMID:35315884 | DOI:10.1001/jama.2022.2518
Source: Atherosclerosis - March 22, 2022 Category: Cardiology Authors: Wendy Wang Michael J Zhang Riccardo M Inciardi Faye L Norby Michelle C Johansen Romil Parikh Jeremy R Van't Hof Alvaro Alonso Elsayed Z Soliman Thomas H Mosley Rebecca F Gottesman Amil M Shah Scott D Solomon Lin Yee Chen Source Type: research
The Leisure Seeker Mijajlovi ćMDPavlovićABraininMHeissWDQuinnTJIhle-HansenHB, and others. 2017. Post-stroke dementia-a comprehensive review. BMC Med2017;15(1):11. PendleburySTRothwellPM; Oxford Vascular Study. 2019. Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the pop ulation-based Oxford Vascular Study. Lancet Neurol2019;18(3):248-58. KotonSPikeJRJohansenMKnopmanDSLakshminarayanKMosleyT, and others. 2022. Association of ischemic stroke incidence, severity, and recurrence with dementia in the Atherosclerosis Risk in Communities Cohort Study. JAMA Neurol2022;79(3) :271-80. SnowdonDAGreinerLHMortimerJARileyKPGreinerPAMarkesberyWR.1997. Brain infarction and the clinical expression of Alzheimer disease: The Nun Study. JAMA1997;277(10):813-7
Neuroscientist. 2022 Apr;28(2):95-96. doi: 10.1177/10738584221090208.NO ABSTRACTPMID:35441539 | DOI:10.1177/10738584221090208
Source: Atherosclerosis - April 20, 2022 Category: Cardiology Source Type: research
