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Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis
Hamostaseologie. 2021 Dec;41(6):447-457. doi: 10.1055/a-1661-1908. Epub 2021 Dec 23.ABSTRACTAtherosclerosis is a chronic inflammatory disease of the arterial wall that leads to the build-up of occluding atherosclerotic plaques. Its clinical sequelae, myocardial infarction and stroke, represent the most frequent causes of death worldwide. Atherosclerosis is a multifactorial pathology that involves traditional risk factors and chronic low-grade inflammation in the atherosclerotic plaque and systemically. This process is accompanied by a strong autoimmune response that involves autoreactive T cells in lymph nodes and atherosc...
Source: Hamostaseologie - December 23, 2021 Category: Hematology Authors: Timoteo Marchini Tijani Abogunloko Dennis Wolf Source Type: research