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Research Articles Disrupting the platelet internal membrane via PI3KC2{alpha} inhibition impairs thrombosis independently of canonical platelet activation
Arterial thrombosis causes heart attacks and most strokes and is the most common cause of death in the world. Platelets are the cells that form arterial thrombi, and antiplatelet drugs are the mainstay of heart attack and stroke prevention. Yet, current drugs have limited efficacy, preventing fewer than 25% of lethal cardiovascular events without clinically relevant effects on bleeding. The key limitation on the ability of all current drugs to impair thrombosis without causing bleeding is that they block global platelet activation, thereby indiscriminately preventing platelet function in hemostasis and thrombosis. Here, we...
Source: Science Translational Medicine - July 21, 2020 Category: Biomedical Science Authors: Selvadurai, M. V., Moon, M. J., Mountford, S. J., Ma, X., Zheng, Z., Jennings, I. G., Setiabakti, N. M., Iman, R. P., Brazilek, R. J., Z. Abidin, N. A., Chicanne, G., Severin, S., Nicholls, A. J., Wong, C. H. Y., Rinckel, J.-Y., Eckly, A., Gachet, C., Nes Tags: Research Articles Source Type: research