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Specialty: Chemistry
Condition: Bleeding
Drug: Warfarin
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Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease Reviews
BACKGROUND:
In 1964, Robert A. O'Reilly's research group identified members of a family who required remarkably high warfarin doses (up to 145 mg/day, 20 times the average dose) to achieve appropriate anticoagulation. Since this time, pharmacogenetics has become a mainstay of cardiovascular science, and genetic variants have been implicated in several fundamental classes of medications used in cardiovascular medicine.
CONTENT:
In this review, we discuss genetic variants that affect drug response to 3 classes of cardiovascular drugs: statins, platelet P2Y12 inhibitors, and anticoagulants. These genetic variations have phar...
Source: Clinical Chemistry - December 29, 2016 Category: Chemistry Authors: Friede, K., Li, J., Voora, D. Tags: Molecular Diagnostics and Genetics Reviews Source Type: research
