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Dabigatran vs. Aspirin for Secondary Prevention After Embolic Stroke of Undetermined Source 　- Japanese Subanalysis of the RE-SPECT ESUS Randomized Controlled Trial.
CONCLUSIONS: Dabigatran was putatively associated with a lower relative risk of recurrent stroke compared with aspirin in Japanese ESUS patients. PMID: 33132228 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 30, 2020 Category: Cardiology Authors: Toyoda K, Uchiyama S, Hagihara Y, Kuwashiro T, Mori T, Kamiyama K, Urano Y, Taniguchi A, Nozaki K, Cronin L, Grauer C, Brueckmann M, Diener HC Tags: Circ J Source Type: research

Efficacy and Safety of Dabigatran Etexilate vs. Warfarin in Asian RE-LY Patients According to Baseline Renal Function or CHADS2 Score.
CONCLUSIONS: Bleeding and stroke rates in Asian patients varied according to renal function and CHADS2score, but the relative benefits of DE over warfarin were preserved when analyzed by subcategories. PMID: 26248573 [PubMed - as supplied by publisher]
Source: Circulation Journal - August 6, 2015 Category: Cardiology Authors: Hori M, Fukaya T, Kleine E, Reilly PA, Ezekowitz MD, Connolly SJ, RE-LY Investigators Tags: Circ J Source Type: research

Clinical Significance of Non-Vitamin K Antagonist Oral Anticoagulants in the Management of Atrial Fibrillation.
Abstract Atrial fibrillation (AF) is the most commonly observed rhythm disorder in clinical practice. It is associated with a high risk of thromboembolic stroke and increased cardiovascular mortality. Vitamin K antagonists (VKAs), the only oral anticoagulants used for thromboembolic prophylaxis in AF patients over the past 60 years, have been effective in reducing thromboembolic stroke, compared with placebo and aspirin, in this group of patients. However, VKAs have a very narrow therapeutic window, so regular monitoring of the therapeutic effect is obligatory for their use. The need for regular assessment of bloo...
Source: Circulation Journal - April 2, 2015 Category: Cardiology Authors: Santarpia G, Curcio A, Sibilio G, Indolfi C Tags: Circ J Source Type: research

Impact of Non-Vitamin K Antagonist Oral Anticoagulants on Intracranial Bleeding in Asian Patients With Non-Valvular Atrial Fibrillation.
Abstract The incidence of intracranial bleeding is known to be markedly higher in Japan and other East Asian countries than in countries outside of East Asia. Non-vitamin K antagonist oral anticoagulants (NOACs) have much lower risk of intracranial bleeding than warfarin, so we reviewed the effect of this class of drugs on intracranial bleeding in Asian patients with non-valvular atrial fibrillation (NVAF). Warfarin therapy in Asian or East Asian populations appears to be associated with lower efficacy, poorer safety and a much greater risk of intracranial bleeding when compared with non-Asian or non-East Asian gr...
Source: Circulation Journal - September 10, 2014 Category: Cardiology Authors: Yasaka M, Lip GY Tags: Circ J Source Type: research